Description
Book SynopsisPathophysiology of Peptic Ulcer Disease.- Decreased Intragastric Acid Concentration as an Approach to Peptic Disease Therapy.- General Approach to Peptic Disease Therapy.- Ulcer Healing by Strengthening of Mucosal Defense.- History of the Development of Sucralfate.- Sucralfate: A Nonsystemic Site Protective Agent.- Chemistry of Sucralfate.- Binding of Bile Acids by Sucralfate.- Mechanisms of Action of Sucralfate.- Binding of Sucralfate to the Mucosal Surface.- Stimulation of Mucus Production.- Gastroduodenal Bicarbonate Secretion and its Response to Sucralfate.- Effect of Sucrose Octasulfate on Isolated Gastric Cells.- Effect on Gastric Surfactant.- Stimulation of Mucosal Prostaglandins by Sucralfate.- Sucralfate and Helicobacter pylori.- Sucralfate and Cell Proliferation.- Vascular Factors.- Sucralfate.- Effects of Sucralfate on Growth Factor Availability.- Duodenal Ulcer Therapy, Acid Rebound, and Early Relapse.- Effect of Sucralfate on Experimental Ulcers.- Effect on Experimental Es
Table of ContentsIntroduction; D. Hollander, G.N.J. Tytgat. Pathophysiology of Peptic Ulcer Disease; F. Halter. Decreased Intragastric Acid Concentration as an Approach to Peptic Disease Therapy; A.B.R. Thomson. Strengthening of Mucosal Defenses as an Approach to Peptic Disease Therapy; A.S. Tarnawski. History of the Development of Sucralfate; A. Ishimori. The Chemistry of Sucralfate; K. Ochi. Binding of Bile Acids by Sucralfate; W.F. Caspary. Binding of Sucralfate to the Mucosal Surface; G. Morris. Stimulation of Mucus Production by Sucralfate; C. TasmanJones. Stimulation of Gastroduodenal Bicarbonate Secretion by Sucralfate; D.W. Rees. Effect of Sucrose Octasulphate on Isolated Gastric Cells; M. Lucey, T. Yamada. Effect of Sucralfate of Gastric Surfactant; B.A. Hills. Stimulation of Mucosal Prostaglandins by Sucralfate; D. Rachmilewitz. Effect of Sucralfate on Helicobacter Pylori; J.A. Louw. Sucralfate and Cell Proliferation; H. Kuwayama. Effect of Sucralfate on Vascular Factors: Mucosal Vasoprotection and Angiogenesis; S. Szabo. Sucralfate Effects on Growth Factor Availability; J. Konturek. 16 additional articles. Index.
