With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:
- Autophagy
Table of Contents
List of Contributors, vii
1 Hepatocytes 1
Jean-François Dufour and Joachim C. Mertens
2 Signaling pathways in biliary epithelial cells 15
M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson
3 Stellate cells 34
Alessandra Caligiuri and Fabio Marra
4 Kupffer cells 61
Amirali Kiyani and Ekihiro Seki
5 Hepatic sinusoidal endothelial cells 73
Moira B. Hilscher Robert C. Huebert and Vijay H. Shah
6 Extracellular matrix 85
Scott L. Friedman
7 Platelets: a new cell type in liver physiology 97
Mickaël Lesurtel and Pierre]Alain Clavien
8 Immune cell communication in liver disease and liver regeneration 110
R. Harminder Boghal, B.F. Stephenson and Simon C. Afford
9 Extracellular vesicle RNA in liver disease 130
Tushar Patel and Hiroaki Haga
10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139
Fabienne Foufelle and Pascal Ferré
11 Autophagy 151
Hao Zhang, Bilon Khambu and Xiao]Ming Yin
12 CXC chemokine receptor signaling in liver repair and regeneration 166
Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch
13 Metabolic regulation of liver regeneration 174
Jiansheng Huang and David A. Rudnick
14 TNF signaling 186
Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg
15 Fas/FasL 203
Maria Eugenia Guicciardi and Gregory J. Gores
16 Interferon signaling 214
Markus H. Heim
17 Endocannabinoid signaling in liver pathologies 226
Bostjan Humar and Nasser Semmo
18 The WNT/β]catenin pathway 240
Satdarshan P. Singh Monga
19 Hedgehog signaling in the liver 262
Mariana V. Machado and Anna Mae Diehl
20 Notch pathway 275
Sonja Rothweiler and David Semela
21 PI3K/PTEN signaling in liver diseases 287
Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti
22 mTOR signaling in liver disease 314
Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall
23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326
Benoit Viollet and Marc Fortes
24 NF-κB 339
Ekihiro Seki and David A. Brenner
25 c-Jun NH2]terminal kinases in liver diseases 348
Johannes Kluwe and Robert F. Schwabe
26 p53 364
Aundrietta D. Duncan, Wen]Wei Tsai and Michelle Craig Barton
27 Sirtuins 374
Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey
28 Bile acids and their receptors 385
Thierry Claudel and Michael Trauner
29 Hepcidin and iron 400
Chiara Vecchi and Antonello Pietrangelo
30 Gut microbiome and liver diseases 411
Herbert Tilg and Alexander R. Moschen
31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421
Jelena Mann and Derek A. Mann
32 Signaling in hepatocellular carcinoma 435
Adam Pennycuick and Augusto Villanueva
33 Interplay between hepatitis B virus and innate immune signaling pathways 448
Barbara Testoni, David Durantel and Fabien Zoulim
34 Signaling of hepatitis C virus 459
Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert
35 Oxidative stress and signaling in the liver 469
Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke
Index 000
