Description

Book Synopsis
Addressing a long-standing challenge for medicinal chemists, this practical reference provides the concepts and tools for developing drug-like small molecules that selectively modulate non-coding RNAs. The introductory parts describes the wide range of druggable RNAs, available techniques for their characterization, binding assay development as well privileged structures in small molecule RNA binders. The main part systematically covers different RNA targets and how to approach them from a drug discovery angle, from splice modulation to riboswitches to targeted degradation, translation blockers and RNA modification. Throughout, the first successful examples of RNA-targeting drug candidates from the development pipeline of small and large pharmaceutical companies are discussed. This seminal reference on a new paradigm in drug discovery is required reading for every medicinal chemists who needs to stay abreast of current developments.

RNA as a Drug Target

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      Book details

      Publisher Wiley-VCH Verlag GmbH
      Published 1 November 2024
      ISBN-13 9783527351008
      978-3527351008
      ISBN-10 3527351000
      Also in:
      Pre-clinical medicine: basic sciences

      Description

      Book Synopsis
      Addressing a long-standing challenge for medicinal chemists, this practical reference provides the concepts and tools for developing drug-like small molecules that selectively modulate non-coding RNAs. The introductory parts describes the wide range of druggable RNAs, available techniques for their characterization, binding assay development as well privileged structures in small molecule RNA binders. The main part systematically covers different RNA targets and how to approach them from a drug discovery angle, from splice modulation to riboswitches to targeted degradation, translation blockers and RNA modification. Throughout, the first successful examples of RNA-targeting drug candidates from the development pipeline of small and large pharmaceutical companies are discussed. This seminal reference on a new paradigm in drug discovery is required reading for every medicinal chemists who needs to stay abreast of current developments.

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