Description
Book SynopsisChemists are now moving away from volatile, environmentally harmful, and biologically incompatible organic solvents. With its low cost, ready availability, and capacity to remove environmentally unfriendly by-products, water is an obvious replacement. Recent advances in free radical chemistry in water have expanded the versatility and flexibility of homolytic carbon-hydrogen, carbon-carbon, carbon-halogen, carbon-nitrogen bond formations in aqueous media. This textbook highlights the substantial progress which has been made in the last decade to "tame" the reactive free radical species in aqueous phase reactions. It describes carbon-hydrogen bond formations in aqueous media via radical reactions with a specific focus on HAT (Hydrogen Atom Transfer). Suitable for students of chemistry, industrial chemists and academic researchers, it combines extensive knowledge of free radical chemistry with the latest innovations and creative applications. Divided into five main areas, it covers the: generation of carbon centred free radicals; radical initiators; solubility of substrate; suitability of free radical hydrogen donors, and HAT reactions in aqueous media. The book describes radical reactions in organic and aqueous media and their applications in total synthesis, DNA structural probing, isotope labelling, living polymerization and various other applications. It shows that, armed with an elementary knowledge of kinetics and some common sense, it is possible to harness radicals into tremendously powerful tools for solving synthetic problems. Written with the needs of students in mind, it offers just the right level of detail for undergraduate study. All the basic principles and facts on each topic area are presented in a concise yet comprehensive style that is appropriate for both core and specialist courses. It provides a step-wise introduction, taking students from the basic principles of radical reactions through to their applications in industry and their role in biological and environmental processes. Case studies are used to illustrate reactions in landmark synthesis and problems, with outlined answers, test the reader's understanding. There are also suggestions for further reading.
Table of ContentsContents: Free Radical Chemistry and Green Chemistry: The historical perspective, Basic Radical Chemistry: General aspects of synthesis with radicals, Why Water as a Solvent? Reasons and Advantages, Reducing agents based Group 4 and Aqueous Media, Hypophosporous acid (H3PO2) as a free radical hydrogen donors in aqueous media, Organoboron Compounds as Radical Reducing Agents, : Carbon-Carbon Bond formation and stereoaspects, Redox Processes and Electron Transfer via Free Radicals, Chain vs Non-Chain Free Radical Processes in Aqueous Media, Future Directions and Practical considerations including methods of radical formation.
