Description
Book SynopsisGeorge Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology.
Trade Review"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal
"It contains many figures of good quality." - Journal of Endocrine Genetics
"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing
Table of ContentsPart I. Molecular Mechanisms in Rheumatic Diseases Genetics Peter K. Gregersen Viruses Andras Perl Apoptosis John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou Humoral Response Gary S. Gilkeson T-Cell Signaling Gary A. Koretzky and Erik J. Peterson Adhesion and Costimulatory Molecules Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler Transcription Factors Henry K. Wong Immune Complexes Mark H. Wener Complement V. Michael Holers Eicosanoids and Other Bioactive Lipids Leslie J. Crofford Collagens Sergio A. Jiménez Part II. Cellular Mechanisms in Rheumatic Diseases T-Lymphocytes Nilamadhab Mishra and Gary M. Kammer B-Lymphocytes Robert F. Ashman Monocytes and Macrophages James M. K. Chan and Sharon M. Wahl Polymorphonuclear Cells Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein Synoviocytes David E. Yocum Chondrocytes Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud Osteoblasts and Osteoclasts Stavros C. Manolagas Animal Models Thomas J. Lang and Charles S. Via Part III. Pathogenesis of Rheumatic Diseases Systemic Lupus Erythematosus Stamatis-Nick C. Liossis and George C. Tsokos Rheumatoid Arthritis Richard M. Pope and Harris Perlman Inflammatory Myopathies Norbert Goebels and Reinhard Hohlfeld Systemic Sclerosis Timothy M. Wright Vasculitis Jörg J. Goronzy and Cornelia M. Weyand Osteoarthritis Robin Poole and Ginette Webb Osteoporosis Stavros C. Manolagas Heritable Disorders of Connective Tissue Petros Tsipouras Part IV. Molecular Aspects of Treatment of RheumaticDiseases Corticosteroids Henry K. Wong and George C. Tsokos Cytotoxic Drugs David A. Fox and W. Joseph McCune Complement Inhibitors Savvas C. Makrides Cytokine Response Modifiers Richard E. Jones and Larry W. Moreland Restoration of Immune Tolerance Woodruff Emlen Metalloproteases and Their Modulation as Treatment in Osteoarthritis Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier Gene Therapy Robert P. Kimberly
