Description

Book Synopsis

In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for undruggable' targets.

FEATURES

A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules.

The database can be used to predict the solubility of research pharmaceutical molecules.

Includes downl

Predicting Solubility of New Drugs

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    £240.00

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    Order before 4pm tomorrow for delivery by Fri 14 Aug 2026.

    A Hardback by Alex Avdeef

    15 in stock

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      Publisher: CRC Press
      Publication Date: Publication Date: 5/27/2024
      ISBN13: 9781032617671, 978-1032617671
      ISBN10: 1032617675
      Also in:
      Medical research

      Description

      Book Synopsis

      In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for undruggable' targets.

      FEATURES

      A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules.

      The database can be used to predict the solubility of research pharmaceutical molecules.

      Includes downl

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