Description
Book SynopsisReviews the role of peripheral receptor mechanisms in the transduction of pain. This title provides a framework for the development of effective rationally-designed analgesic drugs and therapies with and promoting basic and clinical studies on potentially interesting peripheral receptor targets.
Table of ContentsFOREWORD by Lars Arendt-Nielsen. PREFACE.
CONTRIBUTORS.
PART I PERIPHERAL MECHANISM IN CLINICAL PAIN CONDITIONS.
1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions (Barry J. Sessle).
2. Role of Peripheral Mechanisms in Spinal Pain Conditions (Brian E. Cairns and Pradit Prateepavanich).
PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERAL ANALGESICS.
3. Voltage-Gated Sodium Channels in Peripheral Nociceptive Neurons as Targets For the Treatment of Pain (Theodore R. Cummins).
4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi, and Kazutaka Ikeda).
5. Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic Pain (Joe McGivern).
6. Adenosine Receptors (Jana Sawynok).
7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder, Christopher J. Benson and Kathleen A. Sluka).
8. Vanilloid (TRPV1) and Other Transient Receptor Potential Channels (Marcello Trevisani and Arpad Szallasi).
9. Glutamate Receptors (Brian E. Cairns).
10. Serotonin Receptors (Malin Ernberg).
11. Adrenergic Receptors (Antti Pertovaara).
12. Cholinergic Receptors and Botulinum Toxin (Parisa Gazerani).
13. Cannabinoids and Pain Control in the Periphery (Jason J. McDougall).
14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischer and Carlos Amilcar Parada).
15. Calcitonin Gene-Related Peptide and Substance P (Ranjinidevi Ambalavanar and Dean Dessem).
16. Role of Somatostatin and Somatostatin Receptors in Pain (Ujendra Kumar).
17. Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins (Per Alstergren).
18. Neurotrophic Factors and Pain (Peter Svensson).
PART III DELIVERY SYSTEMS.
19. Topical and Systemic Drug Delivery Systems Targeted Drug Therapy (Urs Hafeli and Amit Kale).
20. Gene Therapy for Pain (Marina Mata and David J. Fink).
21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E. Cairns).
Index.
