Description

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

p53 Suppressor Gene

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Paperback / softback by Tapas Mukhopadhyay , Steven A. Maxwell

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This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The... Read more

    Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
    Publication Date: 18/04/2014
    ISBN13: 9783662222775, 978-3662222775
    ISBN10: 3662222779

    Number of Pages: 132

    Non Fiction , Education

    Description

    This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

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