Description
Book SynopsisATP's powerful impact on the heart and blood vessels was first described in 1929, but it was not until the 1970s that ATP was proposed as the 'purinergic' neurotransmitter in autonomic nerves. The door to this area of research was thrown open when receptors for ATP and its ectoenzymatic breakdown product adenosine were first cloned in the early 1990s. Now, rapidly accelerating research has taken scientists beyond the nervous system, to isolate receptors for purines and pyrimidines in many biological systems. Increasing evidence suggests that research into this area may lead to breakthrough applications in treating many of the most pressing health issues of today, including rheumatoid arthritis, osteoporosis, inflammation, and cancer.
Nucleotides and Regulation of Bone Cell Function brings together the most important findings in the field, written by the very pioneers who have energized the research. Covering many aspects of purinergic signaling with regard to osteoblasts, ost
Table of Contents
Purinergic Signaling in Osteoblasts, P2 Nucleotide Receptor Signaling in Osteoclasts, The Role of Purinergic Signaling in the Interactions between Skeletal Cells, Role of Purine and Pyrimidine Nucleotides and Nucleosides in Regulation of Cartilage Metabolism and Chondrocyte Function, ATP Release Mechanisms, Purinergic Signaling in Inflammation and Immunomodulation, Future Directions, Index
