Description
Book SynopsisThe potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a real look into the future via the newest methodologies.
Table of ContentsI. PREGNANCY COMPLICATIONS: SETTING THESCENE. The mother: Adaptation to pregnancy and normal metabolism. Maternal and fetal normal and abnormal nutrition. Great obstetrical syndromes: It’s all in the placenta. Normal and abnormal fetal growth. Preterm labor and birth. Gestational diabetes mellitus. Preeclampsia. Maternal obesity. Maternal health: Immediate, short-, and long-term complications following pregnancy. The fetus and the neonate: Immediate, short-, and long-term impact. Cost of pregnancy complications related to noncommunicable diseases and cost effectiveness of interventions to address them. II. TOWARDS PREDICTIONAND PREVENTION. Integrated system biology approaches to fetal medicine problems. Omics and female reproduction. Maternal genome and pregnancy outcomes. Placental development and omics. Placental metabolomics in obese pregnancies. Methylome and epigenetic markers. Microbiome and pregnancy complications. Small noncoding RNAs as biomarkers for pregnancy complications. Urine metabolomics and proteomics in prenatal health. Metabolomics and perinatal complications. Metabolomics in normal and pathologic pregnancies. Metabolomics in amniotic fluid. Omics and coagulation disorders in pregnancy. Omics and perinatal medicine: Preeclampsia. Single nucleotide polymorphisms and pregnancy complications. Metabolomics and perinatal cardiology. Metabolomics and human breast milk: A unique and inimitable food for infants. Neurodevelopment and placental omics. Early life complications, placental genomics, and risk for neurodevelopmental disorders in offspring. Metabolomics and perinatal asphyxia. Environment, pregnancy complications, and omics. Sleep and pregnancy complications. Maternal plasma cell-free DNA screening: I. Basic science and applications. Maternal plasma cell-free DNA screening: II. Integration into clinical practice. Microarrays. Whole exome and whole genome sequencing
