Description

Book Synopsis

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease.

Key Features:

  • Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver.
  • Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologis

    Table of Contents

    Preface

    Section 1. Mechanisms of NAFLD Development

    1.Historical Perspectives and Clinical Presentation. 2.Epidemiology and Natural History of Non-Alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis. 3.Genetics of NAFLD. 4.Mechanisms of hepatocyte injury and inflammation in NAFLD. 5.The role of the microbiome.

    Section 2. Diagnostic Tests

    6.Simple Algorithms in Primary Care. 7.Ultrasound based techniques in NAFLD. 8.MRI-based technologies. 9.Artificial intelligence in NAFLD diagnosis.

    Section 3. Management

    10.Dietary interventions. 11.Weight Loss Medications. 12.De novo lipogenesis inhibitors. 13.Targeting bile acids (FXRs and FGF19). 14.PPAR agonists. 15.Anti-inflammatory drugs: Metabolic inflammation in NASH as a therapeutic target. 16.Practical Aspects of Pharmacologic Management.

    Section 4. Extrahepatic Manifestations

    17.Endocrinology: Diabetes and other endocrinopathies. 18.Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease. 19.Extrahepatic Gastrointestinal Manifestations of Non-alcoholic Fatty Liver Disease. 20.Extrahepatic and Hepatic cancers.

    Section 5. NAFLD in special populations

    21.NAFLD in Children: Unique Aspects and Controversies. 22.NAFLD in HIV patients. 23.NAFLD in Liver Transplant Recipients. 24.NAFLD in lean individuals.

NeedtoKnow NAFLD

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    £69.99

    Includes FREE delivery

    Order before 4pm today for delivery by Thu 25 Jun 2026.

    A Paperback by Naim Alkhouri, Stephen A. Harrison

    15 in stock


      View other formats and editions of NeedtoKnow NAFLD by Naim Alkhouri

      Publisher: Taylor & Francis Ltd
      Publication Date: 1/8/2023 12:09:00 AM
      ISBN13: 9781032479484, 978-1032479484
      ISBN10: 1032479485

      Description

      Book Synopsis

      Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease.

      Key Features:

      • Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver.
      • Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologis

        Table of Contents

        Preface

        Section 1. Mechanisms of NAFLD Development

        1.Historical Perspectives and Clinical Presentation. 2.Epidemiology and Natural History of Non-Alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis. 3.Genetics of NAFLD. 4.Mechanisms of hepatocyte injury and inflammation in NAFLD. 5.The role of the microbiome.

        Section 2. Diagnostic Tests

        6.Simple Algorithms in Primary Care. 7.Ultrasound based techniques in NAFLD. 8.MRI-based technologies. 9.Artificial intelligence in NAFLD diagnosis.

        Section 3. Management

        10.Dietary interventions. 11.Weight Loss Medications. 12.De novo lipogenesis inhibitors. 13.Targeting bile acids (FXRs and FGF19). 14.PPAR agonists. 15.Anti-inflammatory drugs: Metabolic inflammation in NASH as a therapeutic target. 16.Practical Aspects of Pharmacologic Management.

        Section 4. Extrahepatic Manifestations

        17.Endocrinology: Diabetes and other endocrinopathies. 18.Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease. 19.Extrahepatic Gastrointestinal Manifestations of Non-alcoholic Fatty Liver Disease. 20.Extrahepatic and Hepatic cancers.

        Section 5. NAFLD in special populations

        21.NAFLD in Children: Unique Aspects and Controversies. 22.NAFLD in HIV patients. 23.NAFLD in Liver Transplant Recipients. 24.NAFLD in lean individuals.

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