Description
Book SynopsisEdit A look into the exciting field of chemistry of Natural Products, which is concerned with the substances of nature and the biochemical processes by which they are formed Based on the award winning Wiley Encyclopedia of Chemical Biology Fifteen self contained peer-reviewed articles .
Trade Review“In summary, this is a really good book from a number of prominent research groups who have made important contributions to their fields. Some chapters are well suited for newcomers to the subject, as well as for teaching or for reading by interested students.” (Angewandte Chemie International Edition, 19 March 2014)
Table of ContentsPreface vii
Contributors ix
PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1
1 Plant Natural Products 3
A. Leslie Gunatilaka
2 Marine Natural Products 31
Nobuhiro Fusetani
3 Microbial Natural Products 65
Sergio Sanchez, Silvia Guzma´n-Trampe, Mariana A´valos, Beatriz Ruiz, Romina Rodr´ýguez-Sanoja, and Manuel Jim´enez-Estrada
PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109
4 Nonribosomal Peptides 111
Georg Schoenafinger and Mohamed A. Marahiel
5 Plant Terpenoids 127
Christopher I. Keeling and J¨org Bohlmann
6 Polyketides in Fungi 143
Thomas J. Simpson and Russell J. Cox
7 Modular Polyketide Synthases 163
Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman
8 Polyketide Polyethers 189
Alison M. Hill
9 Alkaloids 209
Sarah E. O’Connor
10 Cofactors 239
Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich
11 Antibiotics 269
Sergey B. Zotchev
PART III NATURAL PRODUCTS IN MEDICINE 287
12 Pharmaceuticals: Natural Products and Natural Product Models 289
Sheo B. Singh
13 Natural Products as Anticancer Agents 325
David G. I. Kingston and David J. Newman
14 Plant-Derived Natural Products Research in Drug Discovery 351
Kuo-Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris-Natschke
Index 389
