Description
Book SynopsisFrank discussions of opportunities and challenges point the way to new, more effective drug delivery systems
Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems.
Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a gen
Table of Contents
Preface vii
Contributors ix
1 Tumor-Targeted Nanoparticles: State-of-the-Art and Remaining Challenges 1
Gaurav Bajaj and Yoon Yeo
2 Applications of Ligand-Engineered Nanomedicines 21
Gayong Shim, Joo Yeon Park, Lee Dong Roh, Yu-Kyoung Oh, and Sangbin Lee
3 Lipid Nanoparticles for the Delivery of Nucleic Acids 51
Yuhua Wang and Leaf Huang
4 Photosensitive Liposomes as Potential Targeted Therapeutic Agents 81
David H. Thompson, Pochi Shum, Oleg V. Gerasimov, and Marquita Qualls
5 Multifunctional Dendritic Nanocarriers: The Architecture and Applications in Targeted Drug Delivery 101
Ryan M. Pearson, Jin Woo Bae, and Seungpyo Hong
6 Chitosan-Based Nanoparticles for Biomedical Applications 129
Heebeom Koo, Kuiwon Choi, Ick Chan Kwon, and Kwangmeyung Kim
7 Polymer–Drug Nanoconjugates 151
Rong Tong, Li Tang, Nathan P. Gabrielson, Qian Yin, and Jianjun Cheng
8 Nanocrystals Production, Characterization, and Application for Cancer Therapy 183
Christin P. Hollis and Tonglei Li
9 Clearance of Nanoparticles During Circulation 209
Seung-Young Lee and Ji-Xin Cheng
10 Drug Delivery Strategies for Combating Multiple Drug Resistance 241
Joseph W. Nichols and You Han Bae
11 Intracellular Trafficking of Nanoparticles: Implications for Therapeutic Efficacy of the Encapsulated Drug 261
Lin Niu and Jayanth Panyam
12 Toxicological Assessment of Nanomedicine 281
Hayley Nehoff, Sebastien Taurin, and Khaled Greish
Index 307
