Major advances in the development of mass isotopomer and positio
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"...is supported by a wealth of illustrations, tables, and exemplary calculations that will aid in comprehension...[an] excellent and much needed textbook." (The Quarterly Review of Biology, March 2007) "...should be required for anyone who desires to know more about metabolic tracer kinetics." (Journal of the American Society for Mass Spectrometry, September 2005)
"...an effective integration of theory and practical implementation...It effectively serves as a teaching textbook as well as a research item." (E-STREAMS, August 2005)
Table of Contents
Preface. Chapter 1. Basic Characteristics of Isotopic Tracers.
Chapter 2. Calculating Specific Activity and Radiation Dosages.
Chapter 3. Calculation of Substance Kinetics: Single-Pool Model.
Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model.
Chapter 5. Mass Spectrometry: Instrumentation.
Chapter 6. Determination of Isotopic Enrichment.
Chapter 7. Measurement of Substrate Oxidation.
Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method.
Chapter 9. Mass Isotopomer Distribution Analysis.
Chapter 10. Glucose Metabolism.
Chapter 11. Lipid Kinetics.
Chapter 12. Whole Body Protein Synthesis and Breakdown.
Chapter 13. Measurement of the Synthesis of Specific Proteins.
Chapter 14. Measurement of Regional or Tissue Protein Breakdown.
Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics.
Chapter 16. Nuclear Magnetic Resonance.
Glossary.
Abbreviations.
Index.
