Description
Book SynopsisThis detailed volume examines the complex study of the assessment of
in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques. Beginning with a section on approaches for chemical analytical and bioanalytical techniques in bioavailability research, the book continues with methods to monitor effects
in situ and conduct bioassays to assess the effects of complex environmental samples. It concludes with descriptions of various computational models. Written for the
Methods in Pharmacology and Toxicology series, chapters feature the kind of expert implementation advice that leads to greater success in the field.
Authoritative and versatile, In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems serves as an ideal guide to aid in tackling the challenge of analyzing and understanding chemical pollution in aquatic systems.
Table of ContentsPart I: Chemical Analytical and Bioanalytical Techniques in Bioavailability Research: Passive Sampling/Dosing and Bioaccumulation Assessments
1. Equilibrium Sampling of Hydrophobic Organic Contaminants in Sediments
Gesine Witt, Julia Bachtin, and Sabine Schäfer
2. Passive Sampling of Waterborne Contaminants
Branislav Vrana, Foppe Smedes, and Klára Hilscherová
3. Using Tenax Extractable Concentrations to Determine the Bioavailable Contaminant Fraction in Sediments
Amanda D. Harwood and Samuel A. Nutile
4. Quantifying Bioaccumulation in the Aquatic Environment
Katrine Borgå and Anders Ruus
Part II: Monitoring of Effects In Situ and Bioassays to Assess the Effects of Complex Environmental Samples
5. In Situ Determination of Genotoxic Effects in Fish Erythrocytes Using Comet and Micronucleus Assays
Paula Suares Rocha, Björn Deutschmann, and Henner Hollert
6. Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios
Amaia Orbea, Eider Bilbao, and Miren P. Cajaraville
7. In Situ Exposure of Aquatic Invertebrates to Detect the Effects of Point and Non-Point Source-Related Chemical Pollution in Aquatic Ecosystems
Mirco Bundschuh and Ralf Schulz
8. Whole Sediment Toxicity Bioassay to Determine Bioavailability and Effects of Aquatic Contaminants Using Zebrafish Embryos
Sabrina Schiwy, Mirna Velki, and Henner Hollert
9. Nematode-Based Effect Assessment in Freshwater Sediments
Arne Haegerbaeumer, Sebastian Höss, and Walter Traunspurger
Part III: Computational Models for Interspecies Comparison and Extrapolation from the Lab to the Field
10. In Vitro-In Vivo Extrapolation to Predict Bioaccumulation and Toxicity of Chemicals in Fish Using Physiologically-Based Toxicokinetic Models
Julita Stadnicka-Michalak and Kristin Schirmer
11. Cross-Species Extrapolation Using a Simplifed In Vitro Tissue Explant Assay in Fish
Bryanna Eisner, Jon Doering, Shawn Beitel, and Markus Hecker
12. Extrapolation of Laboratory-Measured Effects to Fish Populations in the Field
Charles R.E. Hazlerigg
