Description

Book Synopsis
Esophageal squamous cell carcinoma (SCC) has a peculiar geographical distribution, with up to 500-fold variations in incidence between the low- and high-risk regions. The first reports suggesting HPV involvement in both benign and malignant squamous cell tumours of the oesophagus date back to 1982. The rapidly increasing literature on this subject is summarised in this book. Screening studies in high-incidence areas of China using balloon cytology sampling report high prevalence of HPV DNA among asymptomatic subjects, followed by HPV DNA detection in hyperplastic and dysplastic epithelia adjacent to SCC. There are close human parallels to both SCP and SCC in the cattle, linked with BPV4 and alimentary carcinogens (bracken fern). In vitro experiments on HPV-positive cancer cell lines implicate similar molecular mechanisms as involved e.g. in HPV-associated genital carcinogenesis. Taken together, these data suggest that the (multifactorial) etiology of oesophageal cancer differs between the low- and high-incidence geographical areas. Oncogenic HPV types seem to play an important causal role only in the high-incidence regions.

Human Papillomavirus (HPV) Involvement in

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    A Paperback / softback by Kari Syrjänen

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      Book details

      Publisher Nova Science Publishers Inc
      Published 19 August 2010
      ISBN-13 9781608762118
      978-1608762118
      ISBN-10 1608762114
      Also in:
      Oncology

      Description

      Book Synopsis
      Esophageal squamous cell carcinoma (SCC) has a peculiar geographical distribution, with up to 500-fold variations in incidence between the low- and high-risk regions. The first reports suggesting HPV involvement in both benign and malignant squamous cell tumours of the oesophagus date back to 1982. The rapidly increasing literature on this subject is summarised in this book. Screening studies in high-incidence areas of China using balloon cytology sampling report high prevalence of HPV DNA among asymptomatic subjects, followed by HPV DNA detection in hyperplastic and dysplastic epithelia adjacent to SCC. There are close human parallels to both SCP and SCC in the cattle, linked with BPV4 and alimentary carcinogens (bracken fern). In vitro experiments on HPV-positive cancer cell lines implicate similar molecular mechanisms as involved e.g. in HPV-associated genital carcinogenesis. Taken together, these data suggest that the (multifactorial) etiology of oesophageal cancer differs between the low- and high-incidence geographical areas. Oncogenic HPV types seem to play an important causal role only in the high-incidence regions.

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