Description
Book SynopsisTable of ContentsList of contributors xi
Preface xxvii
Acknowledgments xxix
Part 1: INTRODUCTION
1 Cardinal manifestations of cancer 3
James F. Holland, Robert C. Bast, Jr., John C. Byrd,
Carlo M. Croce, Ernest Hawk, Fadlo R. Khuri, Raphael
E. Pollock, Apostolia M. Tsimberadou, Christopher G.
Willett, and Cheryl L.Willman
2 Biological hallmarks of cancer 7
Douglas Hanahan and Robert A.Weinberg
Part 2: TUMOR BIOLOGY
3 Molecular biology, genetics, and translational
models of human cancer 19
Benno Traub, Florian Scheufele, Srinivas R.
Viswanathan, Matthew Meyerson, and David A. Tuveson
4 Oncogenes 49
Marco A. Pierotti, Milo Frattini, Samantha Epistolio,
Gabriella Sozzi, and Carlo M. Croce
5 Tumor suppressor genes 73
Fred Bunz and Bert Vogelstein
6 Epigenetic contributions to human cancer 89
Stephen B. Baylin
7 Cancer genomics and evolution 101
William P. D. Hendricks, Aleksandar Sekulic, Alan H.
Bryce, Muhammed Murtaza, Pilar Ramos, Jessica D.
Lang, Timothy G. Whitsett, Timothy K. McDaniel,
Russell C. Rockne, Nicholas Banovich, and Jeffrey M. Trent
8 Chromosomal aberrations in cancer 125
Megan E. McNerney, Ari J. Rosenberg, and Michelle M.
Le Beau
9 MicroRNA expression in cancer 143
Serge P. Nana-Sinkam, Mario Acunzo, and Carlo M. Croce
10 Aberrant signaling pathways in cancer 151
Luca Grumolato and Stuart A. Aaronson
11 Differentiation therapy 161
Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and
Zhu Chen
12 Cancer stem cells 177
Grace G. Bushnell,Michael D. Brooks, andMax S.Wicha
13 Cancer and cell death 187
John C. Reed
14 Cancer cell immortality: targeting telomerase and
telomeres 201
Ilgen Mender, Zeliha G. Dikmen, and JerryW. Shay
15 Cancer metabolism 211
Natalya N. Pavlova, Aparna D. Rao, Ralph J.
DeBerardinis, and Craig B.Thompson
16 Tumor angiogenesis 223
John V. Heymach, Amado Zurita-Saavedra, Scott
Kopetz, Tina Cascone, MoniqueNilsson, and IreneGuijarro
Part 3: QUANTITATIVE ONCOLOGY
17 Cancer bioinformatics 247
John N.Weinstein
18 Systems biology and genomics 261
Saima Hassan, Joe W. Gray, and LauraM.Heiser
19 Statistical innovations in cancer research 269
J. Jack Lee and Donald A. Berry
20 Biomarker based clinical trial design in the era of
genomic medicine 285
R.Donald Harvey, Yuan Liu, Taofeek K.Owonikoko,
and Suresh S. Ramalingam
21 Clinical and research informatics data strategy for
precision oncology 293
Douglas Hartman, Uma Chandran, Michael Davis,
Rajiv Dhir,William E. Shirey, Jonathan C. Silverstein,
and Michael J. Becich
Part 4: CARCINOGENESIS
22 Chemical carcinogenesis 305
Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris
23 Ionizing radiation 325
David J. Grdina
24 Ultraviolet radiation carcinogenesis 333
James E. Cleaver, Susana Ortiz-Urda, and Sarah Arron
25 Inflammation and cancer 339
Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and
Michael Karin
26 RNA tumor viruses 347
Robert C. Gallo and Marvin S. Reitz
27 Herpesviruses 359
Jeffrey I. Cohen
28 Papillomaviruses and cervical neoplasia 367
Michael F. Herfs, Christopher P. Crum, and KarlMunger
29 Hepatitis viruses and hepatoma 373
HongyangWang
30 Parasites 379
Mervat El Azzouni, Charbel F. Matar, Radwa Galal,
Elio Jabra, and Ali Shamseddine
Part 5: EPIDEMIOLOGY, PREVENTION, AND
DETECTION
31 Cancer epidemiology 391
Veronika Fedirko, Kevin T. Nead, Carrie Daniel, and
Paul Scheet
32 Hereditary cancer syndromes: risk assessment and
genetic counseling 403
Rachel Bluebond, Sarah A. Bannon, Samuel M. Hyde,
Ashley H.Woodson, Nancy Y.-Q. You, Karen H. Lu, and
Banu Arun
33 Behavioral approaches to cancer prevention 425
Roberto Gonzalez and Maher Karam-Hage
34 Diet and nutrition in the etiology and prevention
of cancer 433
Steven K. Clinton, Edward L. Giovannucci, Fred K.
Tabung, and Elizabeth M. Grainger
35 Chemoprevention of cancer 453
Ernest Hawk, Karen C. Maresso, Powel Brown, Michelle
I. Savage, and Scott M. Lippman
36 Cancer screening and early detection 473
OtisW. Brawley
Part 6: CLINICAL DISCIPLINES
37 Clinical cancer genomic diagnostics and modern
diagnostic pathology 493
Katherine Roth, Stephen B. Gruber, and Kevin McDonnell
38 Molecular diagnostics in cancer 505
Zachary L. Coyne, Roshni D. Kalachand, Robert C. Bast
Jr., Gordon B. Mills, and Bryan T. Hennessy
39 Principles of imaging 519
Lawrence H. Schwartz
40 Interventional radiology for the cancer patient 521
Zeyad A. Metwalli, Judy U. Ahrar, andMichael J. Wallace
41 Principles of surgical oncology 531
ToddW. Bauer, Kenneth K. Tanabe, and Raphael E. Pollock
42 Principles of radiation oncology 543
Scott R. Floyd, Justus Adamson, Philip P. Connell, Ralph
R.Weichselbaum, and Christopher G.Willett
43 Principles of medical oncology 553
Apostolia M. Tsimberidou, Robert C. Bast, Jr., Fadlo R.
Khuri, and John C. Byrd
44 Pain and palliative care 567
Laura Van Metre Baum and Cardinale B. Smith
45 Psycho-oncology 577
Diya Banerjee and Andrew J. Roth
46 Principles of cancer rehabilitation medicine 585
Michael D. Stubblefield, Miguel Escalon, Sofia A.
Barchuk, Krina Vyas, and David C.Thomas
47 Integrative oncology in cancer care 593
Gabriel Lopez,Wenli Liu, Santhosshi Narayanan, and
Lorenzo Cohen
48 Health services research 599
Michaela A. Dinan and Devon K. Check
Part 7: INDIVIDUALIZED TREATMENT
49 Precision medicine in oncology drug development 613
Apostolia M. Tsimberidou, Elena Fountzilas, and
Razelle Kurzrock
Part 8: CHEMOTHERAPY
50 Drug development of small molecule cancer
therapeutics in an Academic Cancer Center 631
Christopher C. Coss, Jeffrey T. Patrick, Damien Gerald,
Gerard Hilinski, Reena Shakya, and John C. Byrd
51 Principles of dose, schedule, and combination
therapy 641
Joseph P. Eder and Navid Hafez
52 Pharmacology of small-molecule anticancer agents 655
Zahra Talebi, Sharyn D. Baker, and Alex Sparreboom
53 Folate antagonists 667
Lisa Gennarini, Peter D. Cole, and Joseph R. Bertino
54 Pyrimidine and purine antimetabolites 679
Robert B. Diasio and StevenM. Offer
55 Alkylating agents and platinum antitumor
compounds 693
Zahid H. Siddik
56 DNA topoisomerase targeting drugs 701
AnishThomas, Susan Bates,William D. Figg, Sr., and
Yves Pommier
57 Microtubule inhibitors 717
Giuseppe Galletti and Paraskevi Giannakakou
58 Drug resistance and its clinical circumvention 731
Jeffrey A. Moscow, Shannon K. Hughes, Kenneth H.
Cowan, and Branimir I. Sikic
Part 9: BIOLOGICAL AND GENE THERAPY
59 Cytokines, interferons, and hematopoietic growth
factors 739
Narendranath Epperla,Walter Hanel, and Moshe Talpaz
60 Monoclonal antibody and targeted toxin therapy 755
Robert C. Bast, Jr. andMichael R. Zalutsky
61 Vaccines and immunomodulators 781
Jeffrey Schlom, Sofia R. Gameiro, Claudia Palena, and
James L. Gulley
62 T cell immunotherapy of cancer 789
M. Lia Palomba, Jae H. Park, and Renier Brentjens
63 Cancer immunotherapy 799
Padmanee Sharma, Swetha Anandhan, Bilal A.
Siddiqui, Sangeeta Goswami, Sumit K. Subudhi, Jianjun
Gao, Karl Peggs, Sergio Quezada, and James P. Allison
64 Cancer gene therapy 817
Haruko Tashiro, Lauren Scherer, and Malcolm Brenner
65 Cancer nanotechnology 825
Xingya Jiang, Yanlan Liu, Danny Liu, Jinjun Shi, and
Robert Langer
66 Hematopoietic cell transplantation 833
Qaiser Bashir, Elizabeth J. Shpall, and Richard E. Champlin
Part 10: SPECIAL POPULATIONS
67 Principles of pediatric oncology 847
Theodore P. Nicolaides, Elizabeth Raetz, andWilliam L.
Carroll
68 Cancer and pregnancy 867
Jennifer K. Litton
69 Cancer and aging 877
Ashley E. Rosko, Carolyn J. Presley, Grant R.Williams,
and Rebecca L. Olin
70 Disparities in cancer care 885
OtisW. Brawley
71 Neoplasms in people living with human
immunodeficiency virus 895
Chia-Ching J.Wang and Elizabeth Y. Chiao
72 Cancer survivorship 911
Lewis Foxhall
Part 11: DISEASE SITES
73 Primary neoplasms of the brain in adults 921
Matthew A. Smith-Cohn and Mark R. Gilbert
74 Neoplasms of the eye and orbit 933
Erica R. Alvarez, Claudia M. Prospero Ponce, Patricia
Chevez-Barrios, and Dan S. Gombos
75 Neoplasms of the endocrine glands and pituitary
neoplasms 943
Rui Feng, Chirag D. Gandhi, Margaret Pain, and
Kalmon D. Post
76 Neoplasms of the thyroid 949
Matthew D. Ringel
77 Malignant tumors of the adrenal gland 961
Jeffrey E. Lee, Mouhammed A. Habra, andMatthew T.
Campbell
78 Tumors of the diffuse neuroendocrine and
gastroenteropancreatic system 971
Evan Vosburgh
79 Neoplasms of the head and neck 981
Robert L. Ferris, AdamS. Garden, andNabil F. Saba
80 Cancer of the lung 1005
Daniel Morgensztern, Daniel Boffa, Alexander Chen,
Andrew Dhanasopon, Sarah B. Goldberg, Roy H.
Decker, Siddhartha Devarakonda, Jane P. Ko, Luisa M.
Solis Soto, Saiama N.Waqar, Ignacio I.Wistuba, and
Roy S. Herbst
81 Malignant pleural mesothelioma 1029
Michele Carbone, Daniel R. Gomez, Anne S. Tsao,
Haining Yang, and Harvey I. Pass
82 Thymomas and thymic tumors 1043
Mayur D. Mody,Gabriel L. Sica, Suresh S. Ramalingam,
and Dong M. Shin
83 Tumors of the heart and great vessels 1055
Moritz C.Wyler von Ballmoos and Michael J. Reardon
84 Primary germ cell tumors of the thorax 1061
John D. Hainsworth and Frank A. Greco
85 Neoplasms of the esophagus 1065
MaxW. Sung and Virginia R. Litle
86 Carcinoma of the stomach 1083
Carl Schmidt, Nour Daboul, Carly Likar, and JoshuaWeir
87 Primary neoplasms of the liver 1095
Hop S. Tran Cao, Junichi Shindoh, and Jean-Nicolas
Vauthey
88 Gallbladder and bile duct cancer 1109
Mariam F. Eskander, Christopher T. Aquina, and
Timothy M. Pawlik
89 Neoplasms of the exocrine pancreas 1123
Robert A. Wolff, Donghui Li, AnirbanMaitra, Susan
Tsai, Eugene Koay, and Douglas B. Evans
90 Neoplasms of the appendix and peritoneum 1139
Annie Liu, Diana Cardona, and Dan Blazer
91 Carcinoma of the colon and rectum 1147
Yota Suzuki, Douglas S. Tyler, and Uma R. Phatak
92 Neoplasms of the anus 1169
Alexandre A. A. Jácome and Cathy Eng
93 Renal cell carcinoma 1181
Claude M. Grigg, Earle F. Burgess, Stephen B. Riggs,
Jason Zhu, and Derek Raghavan
94 Urothelial cancer 1191
Derek Raghavan, Richard Cote, Earle F. Burgess, Derek
McHaffie, and Peter E. Clark
95 Neoplasms of the prostate 1201
Ana Aparicio, Patrick Pilie, Devaki S. Surasi, Seungtaek
Choi, Brian F. Chapin, Christopher J. Logothetis, and
Paul G. Corn
96 Tumors of the penis and the urethra 1239
Jad Chahoud, Andrea Necchi, and Philippe E. Spiess
97 Testis cancer 1245
Michael Hawking, Gladell Paner, Scott Eggener, and
Walter M. Stadler
98 Neoplasms of the vulva and vagina 1261
Michael Frumovitz and Summer B. Dewdney
99 Neoplasms of the cervix 1275
Anuja Jhingran
100 Endometrial cancer 1299
Shannon N.Westin, Karen Lu, and Jamal Rahaman
101 Epithelial ovarian, fallopian tube, and peritoneal
cancer 1311
Jonathan S. Berek, Malte Renz, Michael L. Friedlander,
and Robert C. Bast, Jr.
102 Nonepithelial ovarian malignancies 1329
Jonathan S. Berek, Malte Renz, Michael L. Friedlander,
and Robert C. Bast, Jr.
103 Molar pregnancy and gestational trophoblastic
neoplasia 1343
Neil S. Horowitz, Donald P. Goldstein, and Ross S. Berkowitz
104 Gynecologic sarcomas 1351
Jamal Rahaman and Carmel J. Cohen
105 Neoplasms of the breast 1361
Debu Tripathy, Sukh Makhnoon, Banu Arun, Aysegul
Sahin, Nicole M. Kettner, Senthil Damodaran, Khandan
Keyomarsi,Wei Yang, Kelly K. Hunt, Mark Clemens,
Wendy A. Woodward, Melissa P.Mitchell, Rachel
Layman, Evthokia A. Hobbs, Bora Lim, MeganDupuis,
Rashmi Murthy, Omar Alhalabi, Nuhad Ibrahim,
Ishwaria M. Subbiah, and Carlos Barcenas
106 Malignant melanoma 1413
Michael J. Carr, JustinM. Ko, SusanM. Swetter, Scott E.
Woodman, Vernon K. Sondak, Kim A. Margolin, and
Jonathan S. Zager
107 Other skin cancers 1437
Stacy L. McMurray,William G. Stebbins, Eric A.
Millican, and Victor A. Neel
108 Bone tumors 1451
Timothy A. Damron
109 Soft tissue sarcomas 1477
Katherine A.Thornton, Elizabeth H. Baldini, Robert G.
Maki, Brian O’Sullivan, Yan Leyfman, and Chandrajit P. Raut
110 Myelodysplastic syndromes 1501
Uma M. Borate
111 Acute myeloid leukemia in adults: mast cell
leukemia and other mast cell neoplasms 1517
RichardM. Stone, Charles A. Schiffer, and Daniel J. DeAngelo
112 Chronic myeloid leukemia 1537
Jorge Cortes, Richard T. Silver, and Hagop Kantarjian
113 Acute lymphoblastic leukemia 1547
Elias Jabbour, Nitin Jain, Hagop Kantarjian, and Susan
O’Brien
114 Chronic lymphocytic leukemia 1559
Jacqueline C. Barrientos, Kanti R. Rai, and Joanna M. Rhodes
115 Hodgkin lymphoma 1569
David J. Straus and Anita Kumar
116 Clonal hematopoiesis in cancer 1579
Philipp J. Rauch and David P. Steensma
117 Non-Hodgkin’s lymphoma 1587
Arnold S. Freedman and Ann S. LaCasce
118 Mycosis fungoides and Sézary syndrome 1603
Walter Hanel, Catherine Chung, and John C. Reneau
119 Plasma cell disorders 1611
Andrew J. Yee, Teru Hideshima, Noopur Raje, and
Kenneth C. Anderson
120 Myeloproliferative disorders 1633
Jeanne Palmer and Ruben Mesa
Part 12: MANAGEMENT OF CANCER
COMPLICATIONS
121 Neoplasms of unknown primary site 1647
John D. Hainsworth and Frank A. Greco
122 Cancer cachexia 1659
Assaad A. Eid, Rachel Njeim, Fadlo R. Khuri, and
David K.Thomas
123 Antiemetic therapy 1673
Michael J. Berger andDavid S. Ettinger
124 Neurologic complications of cancer 1683
Luis Nicolas Gonzalez Castro, Tracy T. Batchelor, and
Lisa M. DeAngelis
125 Dermatologic complications of cancer
chemotherapy 1701
Anisha B. Patel, Padmavathi V. Karri, and Madeleine Duvic
126 Skeletal complications 1715
Michael A. Via, Ilya Iofin, Jerry Liu, and Jeffrey I. Mechanick
127 Hematologic complications and blood bank
support 1729
Roger Belizaire and Kenneth C. Anderson
128 Coagulation complications of cancer patients 1739
Tzu-FeiWang and Kristin Sanfilippo
129 Urologic complications related to cancer and its
treatment 1747
Omar Alhalabi, Ala Abudayyeh, and Nizar M. Tannir
130 Cardiac complications 1757
Michael S. Ewer, Steven M. Ewer, andThomas M. Suter
131 Respiratory complications 1779
Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez,
Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura,
Ajay Sheshadre, Scott E. Evans, Roberto Adachi,
Michael Kroll, Saadia A. Faiz, Diwakar
D. Balachandran, Selvaraj E. Pravinkumar,
and Burton F. Dickey
132 Gastrointestinal and hepatic complications in
cancer patients 1811
Robert S. Bresalier, Emmanuel S. Coronel, and Hao Chi Zhang
133 Oral complications of cancer and their treatment 1827
Stephen T. Sonis, Anna Yuan, and Alessandro Villa
134 Gonadal complications 1839
RobertW. Lentz and Catherine E. Klein
135 Sexual dysfunction 1849
Leslie R. Schover
136 Endocrine complications and paraneoplastic
syndromes 1855
Sai-Ching J. Yeung and Robert F. Gagel
137 Infections in patients with cancer 1869
Harrys A. Torres, Dimitrios P. Kontoyiannis, and
Kenneth V.I. Rolston
138 Oncologic emergencies 1883
Sai-Ching J. Yeung and Carmen P. Escalante
Part 13: THE FUTURE OF ONCOLOGY
139 A vision for twenty-first century healthcare 1907
Leroy Hood, Nathan D. Price, and James T. Yurkovich
Index 1915
