Description
Book SynopsisThis textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed.
All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College’s BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.
Table of Contents- Cardiac Development and Congenital Heart Disease:
Cardiac Development Biology – Early Mechanisms
Cardiac Development Biology – Late Mechanisms
Cardiomyocyte Structure and Function
Cardiac Morphology – Anatomy of Congenital Heart Disease
Common Congenital Abnormalities
- The Science of Arrhythmia:
Introduction to the Action Potential
Ion transporters and their Properties
Excitation Contraction Coupling
Tachyarrhythmias
Bradyarrhythmias
- The Science of Heart Failure:
Cardiac Contractility – Normal and Pathological
Heart Failure – A Scientific Perspective
Cardiomyopathy
Therapeutics
Novel Therapies
- The Science of Vascular Disease:
The Vasculature – Pharmacological Targets
The Coagulation Cascade and its Therapeutic Modulation
Cellular and Molecular Mechanisms of Atherosclerosis
Cellular and Molecular Mechanisms of Angiogenesis
Endothelial Function and Dysfunction
