Description
Book SynopsisMany researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development.
Table of ContentsForeword: The Origins of GSK-3.
Preface.
Acknowledgments.
Contributors.
Abbreviations.
PART I: CELLULAR FUNCTIONS OF GSK-3.
1. Glycogen Synthase Kinase-3 - an Introductory Synopsis .
2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective.
3. Role of GSK3/Shaggy in neuronal cell biology.
4. The Crystal Structures of Glycogen Synthase Kinase 3.
5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3.
PART II: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY.
6. GSK-3, a Key Player in Alzheimer’s Disease.
7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments.
8. GSK3 and Stem Cells.
9. Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection.
10. Protein Kinase Inhibitors. Assay Development.
11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies.
PART III: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL.
12. Lithium, the Seminal GSK3 Inhibitor.
13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418.
14. TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors.
15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors.
16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors.
Index.
