Description
Book SynopsisMolecular Genetics and Genetic Variation.- Terminology, Concepts, and Models in Genetic Epidemiology.- An Introduction to Epidemiology.- Genetic Distance and Markers Used in Linkage Mapping.- Approaches to Genetic Linkage Analysis.- Fine-Scale Structure of the Genome and Markers Used in Association Mapping.- Genome-Wide Association Studies.- Candidate Gene Association Studies.- Family-Based Association Studies.- Genome Variation: A Review of Web Resources.- Advanced Methods in Twin Studies.- Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology.- Copy Number Variation.- Epigenetic Variation.- Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis.- Coronary Artery Disease: An Example Case Study.- The Genetic Epidemiology of Obesity: A Case Study.
Table of ContentsPart I: Introduction
1. Molecular Genetics and Genetic Variation
Mohammed Elfatih Twfieg and M. Dawn Teare
2. Terminology, Concepts, and Models in Genetic Epidemiology
M. Dawn Teare and Mauro F Santibàñez Koref
3. An Introduction to Epidemiology
Cother Hajat
Part II: Genetic Linkage Mapping
4. Genetic Distance and Markers Used in Linkage Mapping
Kristina Allen-Brady and Nicola J. Camp
5. Approaches to Genetic Linkage Analysis
M. Dawn Teare
Part III: Genetic Mapping by Association
6. Fine-Scale Structure of the Genome and Markers Used in Association Mapping
Karen Curtin and Nicola J. Camp
7. Genome-Wide Association Studies
Mark M. Iles
8. Candidate Gene Association Studies
M. Dawn Teare
9. Family-Based Association Studies
Frank Dudbridge
10. Genome Variation: A Review of Web Resources
Andrew Collins and William Tapper
Part IV: Emerging Themes
11. Advanced Methods in Twin Studies
Jaakko Kaprio and Karri Silventoinen
12. Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology
Nuala A. Sheehan, Sha Meng, and Vanessa Didelez
13. Copy Number Variation
Louise V. Wain and Martin D. Tobin
14. Epigenetic Variation
Kevin Walters
Part V: Case Studies
15. Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis
Hervé Perdry and Françoise Clerget-Darpoux
16. Coronary Artery Disease: An Example Case Study
Jennifer H. Barrett
17. The Genetic Epidemiology of Obesity: A Case Study
Laura Johnson
