Description
Book SynopsisTable of Contents1. Book introduction: Major trends in vitamin D research; 2. Evolution of human skin pigmentation and vitamin D; 3. Photobiology of vitamin D; 4. The activating enzymes of vitamin D metabolism (25- and 1a-hydroxylases); 5. CYP24A1: structure, function, and physiological role; 6. Alternative pathways for vitamin D metabolism; 7. Vitamin Debinding protein; 8. Regulation of renal vitamin D metabolism; 9. Regulation of extra-renal synthesis of 1,25(OH)2D; 10. Structural basis for ligand activity in vitamin D receptor; 11. Genome-wide perspectives on vitamin D receptor actions; 12. Vitamin D, chromatin, and epigenetics; 13. The diverse genomic mechanisms of action of the vitamin D receptor; 14. Vitamin D and microRNAs; 15. Pathway based-analysis of transcriptomic data from vitamin D studies 16. Vitamin D and the kidney; 17. Vitamin D and the calcium-sensing receptor; 18. Regulation of intestinal calcium and phosphate absorption by vitamin D; 19. Vitamin D and FGF23; 20. Osteoclastogenesis and vitamin D; 21. Vitamin D activity in osteoblasts and osteocytes; 22. Cartilage; 23. Vitamin D and bone: an integrated approach; 24. Vitamin D in dentoalveolar and oral health; 25. Role of vitamin D in skin and hair biology; 26. Vitamin D and the cardiovascular system; 27. Vitamin D, brain development and function; 28. Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms; 29. Vitamin D and skeletal muscle; 30. Understanding vitamin D from mouse knockout models; 31. Pharmacology and pharmacokinetics of vitamin D; 32. Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy; 33. The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate; 34. Vitamin D and the placenta; 35. Consequences of perinatal vitamin D deficiency on later bone health; 36. Adolescence and acquisition of peak bone mass; 37. The role of vitamin D in orthopedic surgery; 38. Vitamin D and muscle performance in athletes and older adults; 39. Role in reproductive biology and dysfunction in women; 40. Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease; 41. Vitamin D and the renineangiotensin system; 42. Vitamin D: presence and function in the eye; 43. Adult vitamin D deficiency and adverse brain outcomes 44. Vitamin D and the lung; 45. Design and synthesis of vitamin D analogs; 46. Structure function relationships of VDR ligands; 47. Modulating vitamin D receptore coregulator binding with small molecules; 48. Mass spectrometry assays of vitamin D metabolites; 49. Measurement and quality assessment of total and free 25-hydroxyvitamin D; 50. Vitamin D tissue distribution by mass spectrometry imaging; Index for Volume 1
