Description

Book Synopsis

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

  • In vivo imaging techniques and quantitative analysis

  • Table of Contents

    Preface ix

    contributors xi

    1 Introduction to Molecular Imaging 1
    Vikas Kundra

    2 PET/SPECT: Instrumentation and Imaging Techniques 12
    Yuan-Chuan Tai

    3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45
    Liang Song and Lihong V. Wang

    4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70
    Tatyana Chernenko, Lara Milane, Christian Matthäus, Max Diem, and Mansoor Amiji

    5 A natomical and Functional MRI91
    Edward F. Jackson

    6 Quantitative Imaging in Drug Delivery 125
    Kooresh I. Shoghi

    7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147
    Stephen M. Moerlein and Zhude Tu

    8 Imaging Peptides, Proteins, and Antibody Delivery 192
    Frederik L. Giesel and Clemens Kratochwil

    9 In Vivo Imaging and Delivery of siRNA199
    Zdravka Medarova and Anna Moore

    10 Imaging Cell Therapy 223
    Yajie Liang and Jeff W. M. Bulte

    11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252
    William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins

    12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268
    Jun Zhao and Chun Li

    13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296
    G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline

    14 Cancer Theranostics with Hollow Gold Nanospheres 308
    Wei Lu and Chun Li

    15 Imaging Pulmonary Drug Delivery 333
    Stephen P. Newman

    16 In Vivo Imaging for Validation of Oral Dose Performance 367
    Fiona J. McInnes and Howard N. E. Stevens

    17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389
    Rajesh K. Uthamanthil and Mei Tian

    18 Imaging Transcatheter Delivery to Liver Tumors 412
    Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

    19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426
    Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

    20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432
    Chi-Ming Lee, Katarina Varnäs, and Lars Farde

    Index 449

Drug Delivery Applications of Noninvasive Imaging

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    A Hardback by Chun Li, Mei Tian

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      Publisher: John Wiley & Sons Inc
      Publication Date: 27/12/2013
      ISBN13: 9780470633472, 978-0470633472
      ISBN10: 0470633476
      Also in:
      Pharmacology Chemistry Industrial chemistry and chemical engineering

      Description

      Book Synopsis

      Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

      In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

      Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

      • In vivo imaging techniques and quantitative analysis

      • Table of Contents

        Preface ix

        contributors xi

        1 Introduction to Molecular Imaging 1
        Vikas Kundra

        2 PET/SPECT: Instrumentation and Imaging Techniques 12
        Yuan-Chuan Tai

        3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45
        Liang Song and Lihong V. Wang

        4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70
        Tatyana Chernenko, Lara Milane, Christian Matthäus, Max Diem, and Mansoor Amiji

        5 A natomical and Functional MRI91
        Edward F. Jackson

        6 Quantitative Imaging in Drug Delivery 125
        Kooresh I. Shoghi

        7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147
        Stephen M. Moerlein and Zhude Tu

        8 Imaging Peptides, Proteins, and Antibody Delivery 192
        Frederik L. Giesel and Clemens Kratochwil

        9 In Vivo Imaging and Delivery of siRNA199
        Zdravka Medarova and Anna Moore

        10 Imaging Cell Therapy 223
        Yajie Liang and Jeff W. M. Bulte

        11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252
        William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins

        12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268
        Jun Zhao and Chun Li

        13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296
        G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline

        14 Cancer Theranostics with Hollow Gold Nanospheres 308
        Wei Lu and Chun Li

        15 Imaging Pulmonary Drug Delivery 333
        Stephen P. Newman

        16 In Vivo Imaging for Validation of Oral Dose Performance 367
        Fiona J. McInnes and Howard N. E. Stevens

        17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389
        Rajesh K. Uthamanthil and Mei Tian

        18 Imaging Transcatheter Delivery to Liver Tumors 412
        Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

        19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426
        Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

        20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432
        Chi-Ming Lee, Katarina Varnäs, and Lars Farde

        Index 449

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