Description
Book SynopsisThis is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.
Trade Review"'Significant, important, excellent. It provides a comprehensive 'state of the art' analysis. Not only is dementia in Alzheimer's disease emerging as the greatest challenge for those charged with the health and community care of people who are ageing with an intellectual disability; it is a similar challenge for the dramatically increasing numbers of older people in the general population. The scientific community investigating one of the most serious health challenges facing adults with an intellectual disability is indebted to Dr Vee Prasher and colleagues for this scholarly contribution to the study of the biological correlates of dementia in Alzheimer's disease in adults with Down syndrome. This important collection of the most recent research findings in this field of enquiry will further stimulate efforts to develop treatments that may ameliorate the condition; delay its onset, and ultimately provide means for prevention.' Trevor R Parmenter, in the Foreword"
Table of ContentsOverview of Alzheimer’s disease in Down syndrome. Neuropathology of Alzheimer’s disease in Down syndrome. Genetics, Alzheimer’s disease and Down syndrome. Amyloid beta and tau Proteins in Alzheimer’s disease and Down syndrome. Down syndrome, dementia, and superoxide dismutase. Macrocytosis: a peripheral marker for dementia in Alzheimer’s disease in adults with Down syndrome? Thyroid function, dementia and Down syndrome. Neurophysiological changes associated with dementia in Down syndrome. Neuroimaging studies of persons with Down syndrome. Concluding remarks
