Description
Book SynopsisThe new time-saving revolution in drug discovery.
Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation.
Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world''s leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes:
* Concepts and terms of combinatorial chemistry
* Polymer-supported synthesis of organic compounds
* Macro bead
Table of ContentsPartial table of contents:
Parallel Organic Synthesis Using Parke-Davis Diversomer Technology (S. DeWitt & A. Czarnik).
Polymer-Supported Synthesis of Organic Compounds and Libraries (M. Kurth).
Macro Beads as Microreactors: New Solid- Phase Synthesis Methodology (W. Rapp).
Combinatorial Libraries in Solution: Polyfunctionalized Core Molecules (E. Wintner & J. Rebek).
Solid-Phase Methods in Combinatorial Chemistry (I. Sucholeiki).
Combinatorial Synthesis Exploiting Multiple-Component Condensations, Microchip Encoding, and Resin Capture (R. Armstrong, et al.).
Indexed Combinatorial Libraries: Nonoligomeric Chemical Diversity for the Discovery of Novel Enzyme Inhibitors (M. Pirrung, et al.).
Combinatorial Libraries of Peptides, Proteins, and Antibodies Using Biological Systems (S. Benkovic, et al.).
Index.
