Description
Book SynopsisProvides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy
Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor.
This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of vir
Table of Contents
List of Contributors, vii
Series Foreword, ix
Preface, xi
Part I Delivery Systems
1 Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors, 3
Vincenzo Cerullo, Kilian Guse, Markus Vähä-Koskela, and Akseli Hemminki
2 Retroviruses for Cancer Therapy, 21
Jiehua Zhou, Yue Ding, John C. Burnett, and John Rossi
3 DNA Plasmids for Non-viral Gene Therapy of Cancer, 39
Amer M. Najjar, Judy S.E. Moyes, and Laurence J.N. Cooper
4 Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core Nanoparticles, 61
Andrew B. Satterlee and Leaf Huang
Part II Targeted Expression
5 Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters, 81
Jennifer L. Hsu, Longfei Huo, Chia-Wei Li, Yi-Hsin Hsu, Yan Wang, and Mien-Chie Hung
6 MicroRNAs as Drugs and Drug Targets in Cancer, 97
Hui Ling and George A. Calin
Part III Principles of Clinical Trials in Gene Therapy
7 Regulatory Issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials, 115
Adrian P. Gee and Zhuyong Mei
8 US Regulations Governing Clinical Trials in Gene Therapy, 131
Bambi Grilley
9 Remaining Obstacles to the Success of Cancer Gene Therapy, 151
Malcolm K. Brenner
Index, 157
