Description

Book Synopsis
This book provides an original account of behavioral aspects with important ramifications for the study of transient receptor potential (TRP) channels functioning. It explains, in terms of specified somato-sensory mechanisms and systems, how TRP channels work. Through exploration of animal models by testing paw withdrawal reflexes to thermal and mechanical stimuli, it is shown that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.

Table of Contents
PrefaceAbbreviationsIntroductionPhylogeny of TRP ChannelsStructural-Functional Characteristics of TRP ChannelsA Short Review of TRP SuperfamilyThermo-TRP ChannelsTRP Channels in Physiological Nociception and PainTRP Channels as Therapeutic and Analgesic TargetsTRP Channels and NSAIDsConcluding Remarks and PerspectivesReferencesIndex.

Behavioral Study of Agonist-Evoked Activation of

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    A Paperback / softback by Merab G. Tsagareli

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      Book details

      Publisher Nova Science Publishers Inc
      Published 21 November 2019
      ISBN-13 9781536165012
      978-1536165012
      ISBN-10 1536165018
      Also in:
      Pain and pain management

      Description

      Book Synopsis
      This book provides an original account of behavioral aspects with important ramifications for the study of transient receptor potential (TRP) channels functioning. It explains, in terms of specified somato-sensory mechanisms and systems, how TRP channels work. Through exploration of animal models by testing paw withdrawal reflexes to thermal and mechanical stimuli, it is shown that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.

      Table of Contents
      PrefaceAbbreviationsIntroductionPhylogeny of TRP ChannelsStructural-Functional Characteristics of TRP ChannelsA Short Review of TRP SuperfamilyThermo-TRP ChannelsTRP Channels in Physiological Nociception and PainTRP Channels as Therapeutic and Analgesic TargetsTRP Channels and NSAIDsConcluding Remarks and PerspectivesReferencesIndex.

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