Description

Book Synopsis
This book describes several ways to improve drug localisation and to increase anti-tumour efficacy, such as through drug modifications and through the development of anti-tumour drug delivery systems. Anticancer drugs have little or no specificity, resulting in low tumour concentrations, systemic toxicity and severe side effects. The pharmacological inhibitors of Hsp90, a major cytosolic chaperone, are examined in this book since they are often used in anticancer therapy. Furthermore, polyphenols, an anti-cancer agent which constitutes the most abundant group of antioxidants of normal human food, is discussed as well. Polyphenols protect against oxidative stress and their associated pathologies include inflammation, cancer and coronary heart diseases. Thus, they play an important role as an anticancer agent. Finally, metal-based antitumor drugs, which play an essential role in clinics today, are reviewed. In particular, ruthenium compounds as promising alternatives to platinum-based anticancer drugs.

Anticancer Drugs: Design, Delivery & Pharmacology

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    A Hardback by Peter Spencer, Walter Holt

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      Book details

      Publisher Nova Science Publishers Inc
      Published 4 January 2009
      ISBN-13 9781607410041
      978-1607410041
      ISBN-10 1607410044
      Also in:
      Oncology

      Description

      Book Synopsis
      This book describes several ways to improve drug localisation and to increase anti-tumour efficacy, such as through drug modifications and through the development of anti-tumour drug delivery systems. Anticancer drugs have little or no specificity, resulting in low tumour concentrations, systemic toxicity and severe side effects. The pharmacological inhibitors of Hsp90, a major cytosolic chaperone, are examined in this book since they are often used in anticancer therapy. Furthermore, polyphenols, an anti-cancer agent which constitutes the most abundant group of antioxidants of normal human food, is discussed as well. Polyphenols protect against oxidative stress and their associated pathologies include inflammation, cancer and coronary heart diseases. Thus, they play an important role as an anticancer agent. Finally, metal-based antitumor drugs, which play an essential role in clinics today, are reviewed. In particular, ruthenium compounds as promising alternatives to platinum-based anticancer drugs.

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