Description
Book SynopsisThis book describes nerve agents and vesicants, their decomposition and their degradation products' chemistry as well as their toxicity including a list of detection techniques of nerve agents and their degradation products.
Trade Review“The strength of the book “Analysis of chemical warfare degradation products” is that it gives a short introduction to CWAs in general and provides the reader with a large number of analytical examples.” (Anal Bioanal Chem, 21 February 2012)
Table of ContentsPreface. 1 Historical Milieu.
1.1 Organophosphorus Nerve Agents.
1.2 Blister Agents.
1.3 Sternutator Agents.
1.4 Chemical Weapons Convention (CWC).
1.4.1 Schedule of Chemicals.
1.4.2 Destruction of Chemical Weapons.
References.
2 Toxicity of Chemical Warfare Agents and their Degradation Products.
2.1 Organophosphorus Nerve Agent Toxicity.
2.1.1 Toxicity Mechanism – Acetylcholinesterase Inhibition.
2.1.2 Exposure.
2.1.3 Response, Treatment and Prevention.
2.2 Toxicity of Nerve Agent Degradation Products.
2.2.1 Toxicity of GA (Tabun) Degradation Products.
2.2.2 Toxicity of GB (Sarin) Degradation Products.
2.2.3 Toxicity of GD (Soman) Degradation Products.
2.2.4 Toxicity of GF (Cyclosarin) Degradation Products.
2.2.5 Toxicity of VX Degradation Products.
2.3 Toxicity of Blister Agents.
2.4 Toxicity of Sternutator Agents.
2.4.1 Toxicity of Degradation Products of Sternutator Agents.
References.
3 Analysis of Chemical Warfare Agents.
3.1 Introduction.
3.2 Minimally Invasive Detection Techniques.
3.3 Separation and Detection Techniques.
3.3.1 Capillary Electrophoresis.
3.3.2 Ion Mobility Spectrometry.
3.3.3 Gas Chromatography (GC)/Gas Chromatography-Mass Spectrometry (GC-MS).
3.3.4 Liquid Chromatography (LC)/Liquid Chromatography-Mass Spectrometry (LC-MS).
3.3.5 Desorption Electrospray Ionization and Direct Analysis in Real Time Mass Spectrometry.
References.
4 Chemical Warfare Agent Degradation Products.
4.1 Analysis of Nerve Agent Degradation Products.
4.1.1 Sample Preparation.
4.1.2 Liquid–Liquid Extraction (Pre-concentration).
4.1.3 Solid Phase Extraction (SPE).
4.1.4 Solid Phase Microextraction (SPME).
4.1.5 Stir Bar Sorptive Extraction (SBSE).
4.1.6 Derivatization.
4.2 Analytical Techniques.
4.2.1 Gas Chromatography (GC).
4.2.2 Liquid Chromatography (LC).
4.2.3 Elemental Speciation.
4.2.4 Ion Mobility.
4.2.5 Capillary Electrophoresis.
4.3 Analysis of Sulfur Mustard Degradation Products.
4.4 Analysis of Sternutator Degradation Products.
References.
Appendix.
Index.
