Description
Book SynopsisIndispensable reference source for researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia.
Table of ContentsPart 1 Amino acids: naturally occurring amino acids; chemical synthesis and resolution; physical studies of amino acids; chemical studies of amino acids; analytical methods. Part 2 Peptide synthesis: methods; selected examples; a list of syntheses reported in 1989; purification methods. Part 3 Analogue and conformational studies of peptide hormones and other biologically active peptides: peptide-backbone modifications; conformationally restricted cyclic and bridged analogues; dehydroamino acid analogues; enzyme inhibitors; side-chain interactions studied by residue substitution or deletion and similar modifications; conformational information derived from physical method. Part 4 Cyclic, modified and conjugated peptides: cyclic peptides; modified linear peptides; conjugate peptides. Part 5 Beta-lactam antibiotic chemistry; new natural products; biosynthesis; penicillins and cephalosporins; clavulanic acid and oxapenams; penams; carbapenems, carbacephems and related systems; azetidinones; major structural variants; mechanistic studies, modes of action and degradation. Part 6 Metal complexes of amino acids and peptides: animo acid complexes; peptide complexes.
