Description
Book SynopsisIndispensable reference source for researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia.
Table of ContentsPart 1 Amino Acids, G.C.Barrett: Naturally occurring amino acids; chemical synthesis and resolution of amino acids; physical and stereochemical studies of amino acids; chemical studies; analytical methods. Part 2 Peptide synthesis, D.T.Elmore: methods; synthesis - selected examples; appendix 1 - a list of syntheses reported in 1988; appendix 2 - purification methods. Part 3 Analogue and conformational studies on peptide hormones and other biologically active peptides, J.S.Davies: Peptide-backbone modifications; conformationally restricted cyclic and bridged; defydroamino acid analogues; enzyme inhibitors; side-chain interactions studied by residue substitution or deletion and similar modifications; conformational information derived from physical method. Part 4 Cyclic, modified and conjugated peptides, P.M.Hardy: Cyclic peptides; modified linear peptides; conjugate peptides. Part 5 Lactam antibiotic chemistry, A.V.Stachulski: New natural products; biosynthesis; penicillins and cephalosporins; clavulanic acid and oxapenams; penems; carbapenems and related systems; azetidinones; major structural variants; mechanistic studies on mode of action and degradation. Part 6 Metal complexes of amino acids and peptides, R.W.Hay and K.B.Nolan: amino acids; peptides.
