Search results for ""Author Jorge D. Brioni""

Book SynopsisNeuronal Nicotinic Receptors: Pharmacology and TherapeuticOpportunities Edited by Stephen P. Arneric and Jorge D. Brioni Nicotine''s efficacy in the treatment of pain and anxiolysis, andits usefulness as a memory enhancer, have been suspected for manyyears, but research into the molecular biology of nicotinicacetylcholine receptors (nAChRs) traditionally has focused onsmoking cessation. Now, thanks to recent technological advances inthe molecular biology and electrophysiology of nAChRs, an abundanceof evidence has emerged in support of nAChR ligands in thetreatment of a range of CNS disorders, including Alzheimer''sdisease, Parkinson''s disease, neuropathic pain, attention deficitdisorder, and depression. Featuring contributions from an international team of experts inthe field, this volume provides researchers and clinicians with acomprehensive review of nAChRs, their molecular biology,pharmacology, and clinical implications. Moving from the molecularto the Trade Review"The book consists of a collection of 23 reviewers of 'things nicotonic' written by many...of the world's leaders in the field. Nearly without exception the chapters are chock full of valuable information." --Journal of Medicinal Chemistry, Vol. 42, No. 15, 1999Table of ContentsMOLECULAR BIOLOGY AND BIOCHEMISTRY. Purification and Cloning of Nicotinic Acetylcholine Receptors (J.Lindstrom). Transcriptional Regulation of Neuronal Nicotinic Receptor SubunitGenes (D. Fornasari, et al.). Molecular Composition and Biophysical Characteristics of NicotinicReceptors (J. Ramirez-Latorre, et al.). Desensitization and the Regulation of Neuronal Nicotinic Receptors(M. Marks). Cell Lines as Models for Studies of Nicotinic AcetylcholineReceptors (R. Lukas). Stable Expression of Human Neuronal Nicotinic Receptors (B.Buisson, et al.). PHYSIOLOGICAL ROLES OF NICOTINIC RECEPTORS. Functional Anatomy of Nicotinic Acetylcholine Receptors inMammalian Brain (P. Clarke). Nicotinic Receptor Modulation of Neurotransmitter Release (S.Kaiser & S. Wonnacott). Functional Diversity of Nicotinic Acetylcholine Receptors in theMammalian Central Nervous System: Physiological Relevance (E.Pereira, et al.). Diverse Functions of Neuronal Nicotinic Receptors Determined bySubcellular Location (D. Berg, et al.). Immunosuppressive and Anti-inflammatory Properties of Nicotine (M.Sopori). PHARMACOKINETICS OF NICOTINE-LIKE ALKALOIDS. Pharmacokinetics and Metabolism of Nicotine and Related Alkaloids(N. Benowitz & P. Jacob). Nicotine and Related Compounds as PET and SPECT Ligands (V.Villemagne, et al). MEDICINAL CHEMISTRY. Natural Products as a Source of Nicotinic Acetylcholine ReceptorModulators and Leads for Drug Discovery (M. Holladay, etal.). Nicotinic Cholinergic Receptor Pharmacophores (R. Glennon & M.Dukat). CURRENT AND POTENTIAL THERAPEUTIC APPLICATIONS. Neuronal Nicotinic Receptor Channel Dysfunction in a Human EpilepsySyndrome (D. Bertrand & S. Berkovic). The Role of Nicotine and Nicotinic Receptors in Psychopathology (S.Leonard, et al.). Nicotine and Non-Nicotine Formulations for Smoking Cessation (S.Leischow & G. Cook). Preclinical Evidence on the Neuroprotective Effects of NicotinicLigands (D. Donnelly-Roberts & J. Brioni). Transdermal Nicotine Treatment of Attention Deficit HyperactivityDisorder (E. Levin, et al.). Neuronal Nicotinic Receptors: New Targets in the Treatment of Pain(C. Flores & K. Hargreaves). Subtype-Selective nAChR Agonists for the Treatment of NeurologicalDisorders: SIB-1508Y and SIB-1553A (F. Menzaghi, et al.). Nicotinic Acetylcholine Receptor-Targeted Compounds: A Summary ofthe Development Pipeline and Therapeutic Potential (M. Decker &S. Arneric). Index.

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Book SynopsisProminent Alzheimer''s investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer''s Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.Table of ContentsPartial table of contents: NEUROBIOLOGY OF COGNITION. Structure and Dynamics of Multiple Memory Systems in Alzheimer's Disease (R. Kesner & M. Ragozzino). Monoamine and Acetylcholine Influences on Higher Cognitive Functions in Nonhuman Primates: Relevance to the Treatment of Alzheimer's Disease (A. Arnsten & C. van Dyck). Neuropsychological Features of Alzheimer's Disease (D. Salmon). MOLECULAR ASPECTS OF ALZHEIMER'S DISEASE. Normal Brain Aging and Alzheimer's Disease Pathology (R. Grewal & C. Finch). Neurofibrillary Tangles in Alzheimer's Disease: Clinical and Pathological Implications (C. Clark, et al.). ALZHEIMER'S DRUG DISCOVERY AND DEVELOPMENT. Use of CSF-Based Markers in the Diagnosis of Alzheimer's Disease (P. Seubert, et al.). Development of Muscarinic Agonists for the Symptomatic Treatment of Alzheimer's Disease (J. Jaen & R. Schwarz). Conceptual Issues in Research on Inflammation and Alzheimer's Disease (J. Rogers). Index.

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