Description

Book Synopsis
Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley''s Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.

Table of Contents

VOLUME I: EXPRESSION SYSTEMS & PROCESS DEVELOPMENT

PREFACE xi

CONTRIBUTORS xiii

PART I INTRODUCTION 3

PART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS 7

1 Animal Cells, Suspension Culture 9
John R. Birch

2 Baculovirus Expression Systems 19
Robert D. Possee, Richard B. Hitchman, and Linda A. King

3 Baculovirus Kinetics, Insect Culture 33
Leslie Chan, Steve Reid, and Lars Keld Nielsen

4 Cell Culture, Aseptic Techniques 49
John M. Davis and Kevin L. Shade

5 Cell Cycle in Bioprocesses 71
Mariam Naciri and Mohamed Al-rubeai

6 Cell Growth and Protein Expression Kinetics 85
Dhinakar S. Kompala

7 Cell Viability Measurement 97
Ning Wei and Benjamin Sommer

8 Contamination Detection in Animal Cell Culture 105
Carol Mclean and Colin Harbour

9 Culture Collections and Biological Resource Centers (BRCs) 131
David Smith

10 Culture Preservation 153
Robert L. Gherna

11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 163
Boyke Bunk, Rebekka Biedendieck, Dieter Jahn, and Patricia S. Vary

12 Gene Expression in Human Cells 181
Marco A. Cacciuttolo, Gene Lee, John Chon, and John Lewis

13 Gene expression in Pichia and other methylotroph yeast 195
Koti Sreekrishna

14 Gene Expression in Recombinant Animal Cells and Transgenic Animals 213
Richard M. Twyman and Bruce Whitelaw

15 Inoculum Expansion Methods, Animal Cell Lines 297
Claudia Kloth, Glenn Maclsaac, Haile Ghebremariam, and Alahari Arunakumari

16 Insect Cell Culture 311
Someet Narang, Erik M. Whiteley, Sunyia Hussain, and Michael J. Betenbaugh

17 Kinetics of Microbial Growth 331
Nicolai S. Panikov

18 Microalgae, Mass Culture Methods 371
Emílio Molina Grima, Jose María Fernández Sevilla, and Francisco Gabriel Acién Fernández

19 Microbial Growth Measurement 399
Arthur L. Koch

20 Microbial Media Composition 413
Rosalie J. Cote

21 Microscopic Characterization of Cells 437
Erwin Huebner

22 Mycoplasma Contamination of Cell Cultures 467
Cord C. Uphoff and Hans G. Drexler

23 Protein Glycosylation: Analysis, Characterization, and Engineering 489
Mikael R. Andersen, Jong Hyun Nam, and Susan T. Sharfstein

24 Secretion of Heterologous Proteins, Gram Positive Bacteria 543
Eric Morello, Isabelle Poquet, Philippe Langella

25 Soluble Protein Expression in Bacteria 557
Catherine H. Schein

PART III MEDIA, CELL LINES AND PROCESS DEVELOPMENT 579

26 Animal Cell Culture Media 581
Natarajan Vijayasankaran, Jincai Li, Robert Shawley, Aaron Chen, Masaru Shiratori, Martin Gawlitzek, Feng Li, Robert Kiss, and Ashraf Amanullah

27 Animal Cell Culture, Effects of Osmolality and Temperature 599
James C. Warren and Shyamsundar Subramanian

28 Animal Cell Stability 617
Martin S. Sinacore, Timothy S. Charlebois, Denis Drapeau, Mark Leonard, Scott Harrison, and S. Robert Adamson

29 Animal Cell Types, Hybridomas 635
K. Heilmann and B. Micheel

30 Antibody Production, Human Recombinant 645
Stefan Dübel

31 Antifoams and Pluronic Polyols, Cell Protection 663
David W. Murhammer

32 Biominiaturization of Bioreactors 669
Michael A. Hanson and Govind Rao

33 Inoculum Preparation 699
Craig J.L. Gershater

34 Microcarrier Culture 711
Susan T. Sharfstein and Christian Kaisermayer

35 Monoclonal Antibody Production, Cell Lines 733
Julia F. Markusen and David K. Robinson

36 Plant Cell Culture, Laboratory Techniques 747
Mark Richard Fowler

37 Scale-Up of Biotechnological Processes 759
Marko Zlokarnik

VOLUME II: EQUIPMENT, PROCESS DESIGN, SENSING, CONTROL, AND cGMP OPERATIONS

PREFACE ix

CONTRIBUTORS xi

PART IV BIOREACTOR DESIGN, ENGINEERING, PROCESS SENSING AND CONTROL 789

38 Aeration, Mixing, and Hydrodynamics in Animal Cell Bioreactors 791
Ruben Godoy-Silva, Claudia Berdugo, and Jeffrey J. Chalmers

39 Biocatalytic Membrane Reactors 821
Lidietta Giorno and Enrico Drioli

40 Bioreactor Scale-Down 847
Laura A. Palomares, Alvaro R. Lara, and Octavio T. Ramírez

41 Bioreactor Scale-Up 863
Laura A. Palomares and Octavio T. Ramírez

42 Bioreactors: Airlift Reactors 887
J.C. Merchuk and F. Garcia Camacho

43 Bioreactors, Continuous Culture of Plant Cells 955
H.J.G. Ten Hoopen

44 Bioreactors, Fluidized-Bed 963
Winfried Storhas

45 Bioreactors, Gas-Treatment 979
Graham Andrews and William Apel

46 Bioreactors, Perfusion 995
Wei Wen Su

47 Bioreactors: Rotating Biological Contactors 1013
Susana Cortez, Pilar Teixeira, Rosário Oliveira, and Manuel Mota

48 Bioreactors, Stirred Tank for Culture of Plant Cells 1031
Pauline M. Doran

49 Cell Immobilization, Engineering Aspects 1069
Ronnie Willaert

50 Fermenter/Bioreactor Design 1101
Marvin Charles and Jack Wilson

51 Gas-Holdup in Bioreactors 1137
Christian Sieblist and Andreas Lübbert

52 Immobilization of Proteins and Enzymes, Mesoporous Supports 1147
Martin Hartmann and Dirk Jung

53 Immobilized Cells 1179
Manojlovic Verica, Bugarski Branko, and Nedovic Viktor

54 Immobilized Enzymes 1201
Jose M. Guisan, Lorena Betancor, and Gloria Fernandez-Lorente

55 Impeller Selection, Animal Cell Culture 1219
Alvin W. Nienow

56 Mammalian Cell Bioreactors 1233
Weichang Zhou, Gargi Seth, Maria J. Guardia, and Wei-Shou Hu

57 Mammalian Cell Culture Reactors, Scale-Up 1245
J. Bryan Griffiths

58 Mass Transfer 1261
Yusuf Chisti

59 Oxygen Transfer Rate Determination Methods 1303
Felix Garcia-Ochoa and Emilio Gomez

60 Photobioreactors 1327
Mario R. Tredici, Graziella Chini Zittelli and Liliana Rodolfi

61 Rheological Behavior of Fermentation Fluids 1347
Colin R. Thomas and Grainne L. Riley

62 Rheology of Filamentous Microorganisms, Submerged Culture 1359
Maria Papagianni

63 Sampling and Sample Handling for Process Control 1377
Bo Mattiasson and Martin Hedström

64 Solid State Fermentation, Kinetics 1387
David A. Mitchell, Deidre M. Stuart, and Robert D. Tanner

65 Solid Substrate Fermentation, Automation 1413
Mario Fernández-fernández and J. Ricardo Pérez-correa

66 Stainless Steels 1427
C.P. Dillon

67 Static Mixing, Fermentation Processes 1435
Radu Z. Tudose and Maria Gavrilescu

68 Transfer Phenomena in Multiphase Systems 1451
Rodica-Viorica Roman

PART V PROCESS ANALYTICAL TECHNOLOGIES (PAT) 1469

69 Bioprocess and Fermentation Monitoring 1471
Michael Pohlscheidt, Salim Charaniya, Marco Jenzsch, Christopher Bork, Tim L. Noetzel, and Andreas Luebbert

70 Flow Injection Analysis in Industrial Biotechnology 1493
Elo Harald Hansen and Manuel Miró

71 Fluorescence Techniques for Bioprocess Monitoring 1511
Fabienne Anton, Carsten Lindemann, Bernd Hitzmann, Kenneth F. Reardon, and Thomas Scheper

72 Off-Line Analysis in Animal Cell Culture 1523
Heino Büntemeyer

73 Process Analytical Technology: Strategies for Biopharmaceuticals 1543
Anurag S. Rathore and Gautam Kapoor

74 Vent Gas Analysis 1567
David Pollard and Jens Christensen

PART VI UPSTREAM cGMP OPERATIONS 1585

75 Antibody Manufacture, Disposable Systems 1587
Regine Eibl and Dieter Eibl

76 Bioreactor Operations 1595
David R. Gray

77 Bioreactors, Cell Culture, Commercial Production 1635
Tan-Che Zhou, Wen-Wen Zhou, Weiwei Hu, and Jian-Jiang Zhong

78 Biotransformation, Process Optimization 1665
Lutz Hilterhaus, Andreas Liese, and Udo Kragl

79 Foam Formation and Control in Bioreactors 1679
Frank Delvigne and Jean-Paul Lecomte

80 Pilot Plants, Design and Operation 1695
Beth H. Junker

81 Shear Sensitivity 1719
Yusuf Chisti

82 Sterilization and Decontamination, Bioprocess Equipment 1763
Peter L. Roberts

INDEX 1781

Upstream Industrial Biotechnology 2 Volume Set

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      Publisher: John Wiley & Sons Inc
      Publication Date: Publication Date: 02/04/2013
      ISBN13: 9781118131237, 978-1118131237
      ISBN10: 1118131231

      Description

      Book Synopsis
      Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley''s Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource.

      Table of Contents

      VOLUME I: EXPRESSION SYSTEMS & PROCESS DEVELOPMENT

      PREFACE xi

      CONTRIBUTORS xiii

      PART I INTRODUCTION 3

      PART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS 7

      1 Animal Cells, Suspension Culture 9
      John R. Birch

      2 Baculovirus Expression Systems 19
      Robert D. Possee, Richard B. Hitchman, and Linda A. King

      3 Baculovirus Kinetics, Insect Culture 33
      Leslie Chan, Steve Reid, and Lars Keld Nielsen

      4 Cell Culture, Aseptic Techniques 49
      John M. Davis and Kevin L. Shade

      5 Cell Cycle in Bioprocesses 71
      Mariam Naciri and Mohamed Al-rubeai

      6 Cell Growth and Protein Expression Kinetics 85
      Dhinakar S. Kompala

      7 Cell Viability Measurement 97
      Ning Wei and Benjamin Sommer

      8 Contamination Detection in Animal Cell Culture 105
      Carol Mclean and Colin Harbour

      9 Culture Collections and Biological Resource Centers (BRCs) 131
      David Smith

      10 Culture Preservation 153
      Robert L. Gherna

      11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 163
      Boyke Bunk, Rebekka Biedendieck, Dieter Jahn, and Patricia S. Vary

      12 Gene Expression in Human Cells 181
      Marco A. Cacciuttolo, Gene Lee, John Chon, and John Lewis

      13 Gene expression in Pichia and other methylotroph yeast 195
      Koti Sreekrishna

      14 Gene Expression in Recombinant Animal Cells and Transgenic Animals 213
      Richard M. Twyman and Bruce Whitelaw

      15 Inoculum Expansion Methods, Animal Cell Lines 297
      Claudia Kloth, Glenn Maclsaac, Haile Ghebremariam, and Alahari Arunakumari

      16 Insect Cell Culture 311
      Someet Narang, Erik M. Whiteley, Sunyia Hussain, and Michael J. Betenbaugh

      17 Kinetics of Microbial Growth 331
      Nicolai S. Panikov

      18 Microalgae, Mass Culture Methods 371
      Emílio Molina Grima, Jose María Fernández Sevilla, and Francisco Gabriel Acién Fernández

      19 Microbial Growth Measurement 399
      Arthur L. Koch

      20 Microbial Media Composition 413
      Rosalie J. Cote

      21 Microscopic Characterization of Cells 437
      Erwin Huebner

      22 Mycoplasma Contamination of Cell Cultures 467
      Cord C. Uphoff and Hans G. Drexler

      23 Protein Glycosylation: Analysis, Characterization, and Engineering 489
      Mikael R. Andersen, Jong Hyun Nam, and Susan T. Sharfstein

      24 Secretion of Heterologous Proteins, Gram Positive Bacteria 543
      Eric Morello, Isabelle Poquet, Philippe Langella

      25 Soluble Protein Expression in Bacteria 557
      Catherine H. Schein

      PART III MEDIA, CELL LINES AND PROCESS DEVELOPMENT 579

      26 Animal Cell Culture Media 581
      Natarajan Vijayasankaran, Jincai Li, Robert Shawley, Aaron Chen, Masaru Shiratori, Martin Gawlitzek, Feng Li, Robert Kiss, and Ashraf Amanullah

      27 Animal Cell Culture, Effects of Osmolality and Temperature 599
      James C. Warren and Shyamsundar Subramanian

      28 Animal Cell Stability 617
      Martin S. Sinacore, Timothy S. Charlebois, Denis Drapeau, Mark Leonard, Scott Harrison, and S. Robert Adamson

      29 Animal Cell Types, Hybridomas 635
      K. Heilmann and B. Micheel

      30 Antibody Production, Human Recombinant 645
      Stefan Dübel

      31 Antifoams and Pluronic Polyols, Cell Protection 663
      David W. Murhammer

      32 Biominiaturization of Bioreactors 669
      Michael A. Hanson and Govind Rao

      33 Inoculum Preparation 699
      Craig J.L. Gershater

      34 Microcarrier Culture 711
      Susan T. Sharfstein and Christian Kaisermayer

      35 Monoclonal Antibody Production, Cell Lines 733
      Julia F. Markusen and David K. Robinson

      36 Plant Cell Culture, Laboratory Techniques 747
      Mark Richard Fowler

      37 Scale-Up of Biotechnological Processes 759
      Marko Zlokarnik

      VOLUME II: EQUIPMENT, PROCESS DESIGN, SENSING, CONTROL, AND cGMP OPERATIONS

      PREFACE ix

      CONTRIBUTORS xi

      PART IV BIOREACTOR DESIGN, ENGINEERING, PROCESS SENSING AND CONTROL 789

      38 Aeration, Mixing, and Hydrodynamics in Animal Cell Bioreactors 791
      Ruben Godoy-Silva, Claudia Berdugo, and Jeffrey J. Chalmers

      39 Biocatalytic Membrane Reactors 821
      Lidietta Giorno and Enrico Drioli

      40 Bioreactor Scale-Down 847
      Laura A. Palomares, Alvaro R. Lara, and Octavio T. Ramírez

      41 Bioreactor Scale-Up 863
      Laura A. Palomares and Octavio T. Ramírez

      42 Bioreactors: Airlift Reactors 887
      J.C. Merchuk and F. Garcia Camacho

      43 Bioreactors, Continuous Culture of Plant Cells 955
      H.J.G. Ten Hoopen

      44 Bioreactors, Fluidized-Bed 963
      Winfried Storhas

      45 Bioreactors, Gas-Treatment 979
      Graham Andrews and William Apel

      46 Bioreactors, Perfusion 995
      Wei Wen Su

      47 Bioreactors: Rotating Biological Contactors 1013
      Susana Cortez, Pilar Teixeira, Rosário Oliveira, and Manuel Mota

      48 Bioreactors, Stirred Tank for Culture of Plant Cells 1031
      Pauline M. Doran

      49 Cell Immobilization, Engineering Aspects 1069
      Ronnie Willaert

      50 Fermenter/Bioreactor Design 1101
      Marvin Charles and Jack Wilson

      51 Gas-Holdup in Bioreactors 1137
      Christian Sieblist and Andreas Lübbert

      52 Immobilization of Proteins and Enzymes, Mesoporous Supports 1147
      Martin Hartmann and Dirk Jung

      53 Immobilized Cells 1179
      Manojlovic Verica, Bugarski Branko, and Nedovic Viktor

      54 Immobilized Enzymes 1201
      Jose M. Guisan, Lorena Betancor, and Gloria Fernandez-Lorente

      55 Impeller Selection, Animal Cell Culture 1219
      Alvin W. Nienow

      56 Mammalian Cell Bioreactors 1233
      Weichang Zhou, Gargi Seth, Maria J. Guardia, and Wei-Shou Hu

      57 Mammalian Cell Culture Reactors, Scale-Up 1245
      J. Bryan Griffiths

      58 Mass Transfer 1261
      Yusuf Chisti

      59 Oxygen Transfer Rate Determination Methods 1303
      Felix Garcia-Ochoa and Emilio Gomez

      60 Photobioreactors 1327
      Mario R. Tredici, Graziella Chini Zittelli and Liliana Rodolfi

      61 Rheological Behavior of Fermentation Fluids 1347
      Colin R. Thomas and Grainne L. Riley

      62 Rheology of Filamentous Microorganisms, Submerged Culture 1359
      Maria Papagianni

      63 Sampling and Sample Handling for Process Control 1377
      Bo Mattiasson and Martin Hedström

      64 Solid State Fermentation, Kinetics 1387
      David A. Mitchell, Deidre M. Stuart, and Robert D. Tanner

      65 Solid Substrate Fermentation, Automation 1413
      Mario Fernández-fernández and J. Ricardo Pérez-correa

      66 Stainless Steels 1427
      C.P. Dillon

      67 Static Mixing, Fermentation Processes 1435
      Radu Z. Tudose and Maria Gavrilescu

      68 Transfer Phenomena in Multiphase Systems 1451
      Rodica-Viorica Roman

      PART V PROCESS ANALYTICAL TECHNOLOGIES (PAT) 1469

      69 Bioprocess and Fermentation Monitoring 1471
      Michael Pohlscheidt, Salim Charaniya, Marco Jenzsch, Christopher Bork, Tim L. Noetzel, and Andreas Luebbert

      70 Flow Injection Analysis in Industrial Biotechnology 1493
      Elo Harald Hansen and Manuel Miró

      71 Fluorescence Techniques for Bioprocess Monitoring 1511
      Fabienne Anton, Carsten Lindemann, Bernd Hitzmann, Kenneth F. Reardon, and Thomas Scheper

      72 Off-Line Analysis in Animal Cell Culture 1523
      Heino Büntemeyer

      73 Process Analytical Technology: Strategies for Biopharmaceuticals 1543
      Anurag S. Rathore and Gautam Kapoor

      74 Vent Gas Analysis 1567
      David Pollard and Jens Christensen

      PART VI UPSTREAM cGMP OPERATIONS 1585

      75 Antibody Manufacture, Disposable Systems 1587
      Regine Eibl and Dieter Eibl

      76 Bioreactor Operations 1595
      David R. Gray

      77 Bioreactors, Cell Culture, Commercial Production 1635
      Tan-Che Zhou, Wen-Wen Zhou, Weiwei Hu, and Jian-Jiang Zhong

      78 Biotransformation, Process Optimization 1665
      Lutz Hilterhaus, Andreas Liese, and Udo Kragl

      79 Foam Formation and Control in Bioreactors 1679
      Frank Delvigne and Jean-Paul Lecomte

      80 Pilot Plants, Design and Operation 1695
      Beth H. Junker

      81 Shear Sensitivity 1719
      Yusuf Chisti

      82 Sterilization and Decontamination, Bioprocess Equipment 1763
      Peter L. Roberts

      INDEX 1781

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