Description
Book SynopsisDrug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.
Table of ContentsIntroduction on Positron Emission Tomography; Aspects on Drug Development in Pharmaceutical Industry; Regulations; Radiochemistry Development (11C and 18F); Design of PET-Tracers; Use of Radiolabelled Antibodies; Animal Models; MicroPET - Practical Aspects; Nonhuman Primates; Small Animal Imaging Cameras; New Clinical Cameras; Multimodality Imaging; Kinetic Modelling and Quantification; Cyclotrons; Lung Studies; Drugs and the Blood Brain Barrier; Oncology; Cardiology; Brain Neurology; Brain Psychiatry; Inflammation; The Role of CROs; Ethical Issues; Advantages and Limitations of PET.
