Description

Book Synopsis

Since their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled.

These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species.

These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms.

While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a chall

Transposable Elements and Genome Evolution

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    A Hardback by Hua–Van

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      Book details

      Publisher ISTE Ltd
      Published 9/17/2024
      ISBN-13 9781789451788
      978-1789451788
      ISBN-10 1789451787
      Also in:
      Science & Nature Genetics (non-medical)

      Description

      Book Synopsis

      Since their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled.

      These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species.

      These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms.

      While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a chall

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