Description
Book SynopsisThis text aims to offer comprehensive coverage of current transcription factor data in the field of experimental haematology and transcription factor biology. Written by established experts in the field, it offers a presentation of cell lineage development.
Trade Review"The researchers who work actively on these issues will find this book to be a source of discussion and references." (International Journal of Hematology, October 2001)
Table of ContentsPartial table of contents: INTRODUCTORY CHAPTER.
Transcription Factors in Normal and Malignant Hematopoiesis: An Overview (K. Ravid & J. Licht).
TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES.
The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation (A. Tsang, et al.).
Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2 (S.-W. Kim & R. Shivdasani).
EKLF and the Development of the Erythroid Lineage (J. Bieker).
TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE.
CBFA2(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages (N. Speck & E. Dzierzak).
PU.1 and the Development of the Myeloid Lineage (D. Tenen).
Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation (V. Bromleigh, et al.).
TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE.
The Role of Ikaros-Family Genes in Lymphocyte Differentiation and Proliferation (N. Avitahl, et al.).
The Role of PU.1 in B-Lymphocyte Development and Function (S. Rao & M. Simon).
The Role of Octamer Transcription Factors in the Lymphoid System (E. Bertolino, et al.).
The Role of Early B-Cell Factor in B Lymphocyte Development (M. Sigvardsson).
LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATIONS INVOLVING GENES ENCODING TRANSCRIPTION FACTORS.
The Role of RAR and its Fusion Partners in Acute Promyelocytic Leukemia (A. Melnick & J. Licht).
The Leukemogenic Function of the Inv(16) Fusion Gene CBFB-MYH11 (P. Liu, et al.).
The TEL-AML-1 Translocation (G. Gilliland & T. Golub).
The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations (G. Blobel).
ONCOGENESIS AND HEMATOPOIESIS.
The Roles of the C-Myc and B-Myb Oncogenes in Hematopoiesis and Leukemogenesis (M. Arsura & G. Sonenshein).
SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES.
Transcription Factors Implicated in Hematopoiesis: In Vivo Studies (Y. Kaluzhny & K. Ravid).
