Description

Book Synopsis
Practical drug development approaches presented by leading experts

Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors'' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.

Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:

  • Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the pr

    Table of Contents
    Preface ix

    About the Editors xi

    Contributors xiii

    Part One Current Science, Skin Permeation, and Enhancement Approaches

    1. Skin Structure, Function, and Permeation 3
    Heather A.E. Benson

    2. Passive Skin Permeation Enhancement 23
    Majella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft

    3. Electrical and Physical Methods of Skin Penetration Enhancement 43
    Jeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts

    4. Clinical Applications of Transdermal Iontophoresis 67
    Dhaval R. Kalaria, Sachin Dubey, and Yogeshvar N. Kalia

    5. In Vitro Skin Permeation Methodology 85
    Barrie Finnin, Kenneth A. Walters, and Thomas J. Franz

    6. Skin Permeation Assessment: Tape Stripping 109
    Sandra Wiedersberg and Sara Nicoli

    7. Skin Permeation Assessment: Microdialysis 131
    Rikke Holmgaard, Jesper B. Nielsen, and Eva Benfeldt

    8. Skin Permeation: Spectroscopic Methods 155
    Jonathan Hadgraft and Majella E. Lane

    9. Skin Permeation Assessment in Man: In Vitro–In Vivo Correlation 167
    Paul A. Lehman, Sam G. Raney, and Thomas J. Franz

    10. Risk Assessment 183
    Jon R. Heylings

    Part Two Topical and Transdermal Product Development

    11. An Overview of Product Development from Concept to Approval 203
    Adam C. Watkinson

    12. Regulatory Aspects of Drug Development for Dermal Products 217
    William K. Sietsema

    13. Toxicological and Pre-clinical Considerations for Novel Excipients and New Chemical Entities 233
    Andrew Makin and Jens Thing Mortensen

    14. Topical Product Formulation Development 255
    Marc B. Brown, Robert Turner, and Sian T. Lim

    15. Transdermal Product Formulation Development 287
    Kenneth J. Miller

    16. Sensitivity and Irritation Testing 309
    Belum Viswanath Reddy, Geetanjali Sethi, and Howard I. Maibach

    17. New Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity 345
    Hugh Alsop

    18. Transdermal and Topical Drug Delivery Today 357
    Adam C. Watkinson

    19. Current and Future Trends: Skin Diseases and Treatment 367
    Simon G. Danby, Gordon W. Duff, and Michael J. Cork

    Index 409

Topical and Transdermal Drug Delivery

    Product form

    £114.26

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    RRP £126.95 – you save £12.69 (9%)

    Order before 4pm today for delivery by Wed 24 Jun 2026.

    A Hardback by HAE Benson, Adam C. Watkinson


      View other formats and editions of Topical and Transdermal Drug Delivery by HAE Benson

      Publisher: Wiley
      Publication Date: 27/01/2012
      ISBN13: 9780470450291, 978-0470450291
      ISBN10:

      Description

      Book Synopsis
      Practical drug development approaches presented by leading experts

      Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors'' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.

      Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:

      • Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the pr

        Table of Contents
        Preface ix

        About the Editors xi

        Contributors xiii

        Part One Current Science, Skin Permeation, and Enhancement Approaches

        1. Skin Structure, Function, and Permeation 3
        Heather A.E. Benson

        2. Passive Skin Permeation Enhancement 23
        Majella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft

        3. Electrical and Physical Methods of Skin Penetration Enhancement 43
        Jeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts

        4. Clinical Applications of Transdermal Iontophoresis 67
        Dhaval R. Kalaria, Sachin Dubey, and Yogeshvar N. Kalia

        5. In Vitro Skin Permeation Methodology 85
        Barrie Finnin, Kenneth A. Walters, and Thomas J. Franz

        6. Skin Permeation Assessment: Tape Stripping 109
        Sandra Wiedersberg and Sara Nicoli

        7. Skin Permeation Assessment: Microdialysis 131
        Rikke Holmgaard, Jesper B. Nielsen, and Eva Benfeldt

        8. Skin Permeation: Spectroscopic Methods 155
        Jonathan Hadgraft and Majella E. Lane

        9. Skin Permeation Assessment in Man: In Vitro–In Vivo Correlation 167
        Paul A. Lehman, Sam G. Raney, and Thomas J. Franz

        10. Risk Assessment 183
        Jon R. Heylings

        Part Two Topical and Transdermal Product Development

        11. An Overview of Product Development from Concept to Approval 203
        Adam C. Watkinson

        12. Regulatory Aspects of Drug Development for Dermal Products 217
        William K. Sietsema

        13. Toxicological and Pre-clinical Considerations for Novel Excipients and New Chemical Entities 233
        Andrew Makin and Jens Thing Mortensen

        14. Topical Product Formulation Development 255
        Marc B. Brown, Robert Turner, and Sian T. Lim

        15. Transdermal Product Formulation Development 287
        Kenneth J. Miller

        16. Sensitivity and Irritation Testing 309
        Belum Viswanath Reddy, Geetanjali Sethi, and Howard I. Maibach

        17. New Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity 345
        Hugh Alsop

        18. Transdermal and Topical Drug Delivery Today 357
        Adam C. Watkinson

        19. Current and Future Trends: Skin Diseases and Treatment 367
        Simon G. Danby, Gordon W. Duff, and Michael J. Cork

        Index 409

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