Description
Book SynopsisUsed routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation.
The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separa
Table of Contents
Part I Theory of Thin Layer Chromatography in Context of Pharmaceutical Analysis. Overview of Drug Analysis and Structure of the Book. Chemistry of Drugs and Its Influence on Retention. Sorbents and Layers Used in Drug Analysis. Optimization of Mobile Phase Composition. Chromatographic Analysis of Ionic Drugs. Ionic Liquid Additives to Mobile Phases. Chromatographic Analysis of Chiral Drugs. Chambers, Sample Application, and New Devices in the Chromatography of Drugs. 2D Planar Chromatography. Quantitative Detection of Drugs by Densitometry and Video Scanning. Statistical Evaluation and Validation of Quantitative Methods of Drug Analysis. Detection and Identification in TLC Drug Analysis. TLC Determination of Drug Lipophilicity. Screening of Substandard and Fake Drugs in Underdeveloped Countries by TLC. Part II Planar Chromatography of Particular Drug Groups. TLC of Antidepressants and Neuroleptics. TLC of Anxiolytics and Sedatives. TLC of Morphine Analogs. TLC of Nonopioid Analgesics, Anti-Inflammatics, and Antimigraine Drugs. TLC of Ergot Alkaloid Derivatives. Thin-Layer Chromatography of Anesthetics. TLC of Psychostimulants. TLC of Antiepileptics. TLC of Alzheimer’s Disease Medicines. TLC of Antiparkinsonians. Thin-Layer Chromatography of Cardiac Drugs. TLC of Antihypertensive and Antihypotensive Drugs. TLC of Beta-Blockers and Beta-Agonists. TLC of Antithrombotics. TLC of Antihyperlipidemics. TLC of Spasmolytics. TLC of Mucolytic, Antitussive, and Antiasthmatic Drugs. TLC of Neuromuscular Blockers. TLC of Antiulcers. TLC of Antiemetic Drugs. TLC of Steroids and Analogs. TLC of Drugs Used in Obesity and Sexual Dysfunction Treatment. TLC of Prostaglandins. TLC of Diuretics. TLC of Antidiabetics. TLC of Antihistamines. TLC of Vitamins Including Nicotinic Acid Derivatives. TLC of Antiseptics. TLC of Sulfonamides. TLC of Quinolones. Thin-Layer Chromatography of Tuberculostatic Drugs. TLC of Antifungal and Antiprotozoal Drugs. TLC of β-Lactam Antibiotics. TLC of Other Antibiotics. Thin-Layer Chromatography of Antiviral Drugs. Thin-Layer Chromatography of Anticancer Drugs. Uncertainty Factors in the Enantioseparation of Chiral Drugs on Silica Gel Layers. Index.
