Description
Book SynopsisThermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of thermophilic life forms at the molecular level with an emphasis on design strategies.
The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers:
- Computing and simulation methods in current and future thermostability research, especially in nonempirical situations
- How rigidity theory is used to improve the thermal adaptation of mesophiles
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Table of Contents
Delineation of the Conformational Thermostability of Hyperthermophilic Proteins Based on Structural and Biophysical Analyses. Role of Packing, Hydration, and Fluctuations on Thermostability. Analyzing Protein Rigidity for Understanding and Improving Thermal Adaptation. Thermostable Subtilases (Subtilisin-Like Serine Proteinases). Combined Computational and Experimental Approaches to Sequence-Based Design of Protein Thermal Stability. Designing Thermophilic Proteins: A Structure-Based Computational Approach. Index.
