Description
Book SynopsisUpdated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
Table of ContentsPreface xi
Open-Chain Compounds 1
Peptidomimetic Compounds 2
Antiviral Protease Inhibitors 2
Human Immunodeficiency Virus 2
Human Rhinovirus 9
Miscellaneous Peptidomimetic Compounds 11
References 19
Alicyclic Compounds 21
Monocyclic Compounds 21
Prostaglandins 21
Antiviral Agents 25
Miscellaneous Monocyclic Compounds 29
Polycyclic Compounds: Steroids 31
19-Nor Steroids 31
Corticosteroid Related Compounds 34
Polycyclic Compounds / 38
References 40
Monocyclic Aromatic Compounds 43
Arylcarbonyl Derivatives 43
Biphenyls 47
Compounds Related to Aniline 50
Compounds Related to Arylsulfonic Acids 53
Diarylmethanes 58
Miscellaneous Monocyclic Aromatic Compounds 60
References 67
Carbocyclic Compounds Fused to a Benzene Ring 69
Indenes 69
Naphthalenes 73
Tetrahydronaphthalenes 74
Other benzofused carbocyclic compounds 79
References 81
Five-Membered Heterocycles 83
Compounds with One Heteroatom 83
Compounds with Two Heteroatoms 91
Oxazole and Isoxazoles 91
Imidazoles and a Pyrrazole 94
Thiazoles 99
Triazoles 103
Tetrazoles 109
References 112
Six-Membered Heterocycles 115
Compounds with One Heteroatom 115
Pyridines 115
Reduced Pyridines 117
Miscellaneous 119
Compounds with Two Heteroatoms 121
Pyrimidines 121
Miscellaneous Six-Membered Heterocycles 133
References 136
Five-Membered Heterocycles Fused to One Benzene Ring 139
Compounds with One Heteroatom 139
Benzofurans 139
Indoles 141
Indolones 148
Miscellaneous Compounds with One Heteroatom 153
Five-Membered Rings with Two Heterocyclic Atoms 156
Benzimidazoles 156
Miscellaneous Compounds 158
References 160
Six-Membered Heterocycles Fused to One Benzene Ring 163
Compounds with One Heteroatom 163
Benzopyrans 163
Quinolines and Their Derivatives 167
Quinolone Antibacterial Agents 172
Compounds with Two Heteroatoms 176
Benzoxazines 176
Quinazolines 178
Miscellaneous Benzo-Fused Heterocycles 184
References 186
Bicyclic Fused Heterocycles 189
Compounds with Five-Membered Rings Fused to Six-Membered Rings 189
Compounds with Two Heteroatoms 189
Compounds with Three Heteroatoms 191
Compounds with Four Heteroatoms 195
Compounds with Two Fused Six-Membered Rings 208
Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams 213
References 215
Polycyclic Fused Heterocycles 217
Compounds with Three Fused Rings 217
Compounds with Four Fused Rings 228
Compounds with Five or More Fused Rings: Camptothecins 230
References 232
Subject Index 233
Cross Index of Biological Activity 241
Cumulative Index 245
