Description
Book SynopsisExploring the importance of Richard F. Heck's carbon coupling reaction, this book highlights the subject of the 2010 Nobel Prize in Chemistry for palladium-catalyzed cross couplings in organic synthesis, and includes a foreword from Nobel Prize winner Richard F. Heck.
Trade Review"It is by far the most authoritative book in this area written to date and has employed many of the major contributors in the area over recent years to provide chapters, resulting in good...coverage of the literature." (
Applied Organimetallic Chemistry , March 2010)
“I am convinced that this book will rapidly become the most important reference text for research chemists in academia and industry who seek orientation in the rapidly growing and – for the layman – confusing field described as the “’Mizoroki–Heck reaction’.” (
Synthesis, March 2010)
"This book is a welcome addition to the subject and provides almost all the areas you would want to be covered." (Organic Process Research & Development Journal, 2010)
"The selection and clear arrangement of the competently written chapters of this book is well done, giving a rapid general overview of current knowledge about various aspects of this important reaction." (Angewandte Chemie December 2009)
Table of ContentsForeword by Professor Richard F. Heck 1 Mechanisms of the Mizoroki–Heck Reaction
Anny Jutand
2 Focus on Catalyst Development and Ligand Design
Irina P. Beletskaya and Andrei V. Cheprakov
3 Focus on Regioselectivity and Product Outcome in Organic Synthesis
Peter Nilsson, Kristofer Olofsson and Mats Larhed
4 Waste-Minimized Mizoroki–Heck Reactions
Lukas Gooßen and Käthe Gooßen
5 Formation of Carbocycles
Axel B. Machotta and Martin Oestreich
6 Formation of Heterocycles
Thierry Muller and Stefan Bräse
7 Chelation-Controlled Mizoroki–Heck Reactions
Kenichiro Itami and Jun-ichi Yoshida
8 The Mizoroki–Heck Reaction in Domino Processes
Lutz F. Tietze and Laura M. Levy
9 Oxidative Heck-Type Reactions (Fujiwara–Moritani Reactions)
Eric M. Ferreira, Haiming Zhang and Brian M. Stoltz
10 Mizoroki–Heck Reactions with Metals Other than Palladium
Lutz Ackermann and Robert Born
11 Ligand Design for Intermolecular Asymmetric Mizoroki–Heck Reactions
Anthony G. Coyne, Martin O. Fitzpatrick and Patrick J. Guiry
12 Intramolecular Enantioselective Mizoroki–Heck Reactions
James T. Link and Carol K. Wada
13 Desymmetrizing Heck Reactions
Masakatsu Shibasaki and Takashi Ohshima
14 Combinatorial and Solid-Phase Syntheses
Thierry Muller and Stefan Bräse
15 Mizoroki–Heck Reactions: Modern Solvent Systems and Reaction Techniques
Werner Bonrath, Ulla L´etinois, Thomas Netscher and Jan Schütz
16 The Asymmetric Intramolecular Mizoroki–Heck Reaction in Natural Product Total Synthesis
Amy B. Dounay and Larry E. Overman
