Description
Book SynopsisTaken together, the body of information contained in this book provides readers with a bird's-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together.
Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA
New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in maki
Table of Contents
1. Introduction to Basic Concepts in Immunology 2. Overview of Mechanistic Modeling: Techniques, Approximations, and Assumptions 3. The Fundamentals of Statistical Data Analysis 4. Using Data to Guide Model Construction: Application of Principal Component Analysis and Related Methods in Immunology Research 5. An Introduction to Rule-based Modeling of Immune Receptor Signaling 6. Boolean Models in Immunology 7. From evolutionary computation to phenotypic spandrels: inverse problem for immune ligand recognition 8. Zen and the Art of Parameter Estimation in Systems Biology 9. Spatial Kinetics in Immunological Modeling 10. Analysis and modeling of single cell data 11. Quantifying lymphocyte receptor diversity 12. Antigen receptor diversification during immune responses 13. Quantitative Modeling of Mast Cell Signaling 14. Physical models in immune signaling 15. Population Dynamics of Host and Pathogens 16. Viral fitness landscapes: A physical sciences perspective 17. A wish-list for modeling immunological synapses
