Description
Book SynopsisBuilding on decades of “host-guest” research, recent years have seen a surge of activity in water-soluble supramolecular receptors for protein recognition and assembly. Progress has been particularly rich in the area of calixarenes, cucurbiturils and molecular tweezers. Emerging applications include controlled protein assembly in solution, crystal engineering, supramolecular control of catalysis (both in vitro and in vivo), as well as novel mechanisms of protein-interaction inhibition with relevance to amyloids and disease. One challenge at the interface of supramolecular chemistry and protein science is to increase interaction and collaboration between chemists and biochemists/structural biologists.This book addresses the exciting interface of supramolecular chemistry and protein science. Chapters cover supramolecular approaches to protein recognition, assembly and regulation. Principles outlined will highlight the opportunities that are readily accessible to collaborating chemists and biochemists, enriching the breadth and scope of this multidisciplinary field. Supramolecular Protein Chemistry will be of particular interest to graduate students and researchers working in supramolecular chemistry, protein science, self-assembly, biomaterials, biomedicine and biotechnology.
Table of ContentsSupramolecular Approaches to Protein Recognition; Macrocycles for Recognition and Sensing of Histone Modifications; Sequence Predictive Recognition of Proteins and Peptides by synthetic and Natural Receptors; Protein Modulation by Cucurbiturils; Supramolecular Nanoassemblies Based on Proteins and Cyclodextrin Derivatives; Molecular Tweezers and Clips that Modify Protein Function; Molecular Glues for Protein Assembly; The Inducing Ligand Strategy for Supramolecular Protein Assembly; Functional Protein-(Bio)Polymer Assemblies
