Description
Book SynopsisSets forth an important group of environmentally friendly organic reactions
With contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C?C), carbon-nitrogen (C?N), and carbon-halogen (C?X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry.
Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The
Trade Review
“The book is nicely structured and the chapters are extensively supplemented by references, offering the reader a practical overview of the field of asymmetric organocatalysis . . . Congratulations to the editor and to all the authors for this nice piece of work.” (Angew. Chem. Int. Ed, 1 October 2014)
Table of ContentsPREFACE vii
CONTRIBUTORS ix
1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1
Ramon Rios and Xavier Companyó
2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS 11
Albert Moyano
3. C–C BOND FORMATION BY ALDOL REACTION 81
Dorota Gryko and Dominika Walaszek
4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129
Armando Córdova
5. C–C BOND FORMATION BY MICHAEL REACTION 147
Yong Zhang and Wei Wang
6. C–C BOND FORMATION BY DIELS–ALDER AND OTHER PERICYCLIC REACTIONS 205
Johan Franzén
7. N-HETEROCYCLIC CARBENE-CATALYZED C–C BOND FORMATION 231
Xiang-Yu Chen and Song Ye
8. a-ALKYLATION OF CARBONYL COMPOUNDS 267
Marek Remeš and Jan Veselý
9. OTHER REACTIONS FOR C–C BOND FORMATION 313
Yi-Xia Jia and Tiexin Zhang
10. CASCADE REACTIONS FORMING C–C BONDS 351
Ramon Rios, Jorge Esteban, and Xavier Companyó
11. ORGANOCATALYTIC C–N BOND FORMATION 381
Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide, and Claudio Palomo
12. C–O BOND FORMATION 433
José Alemán and Mariola Tortosa
13. CARBON–HALOGEN BOND FORMATION 465
Stacey E. Brenner-Moyer
14. C–OTHER ATOM BOND FORMATION (S, SE, B) 493
Giorgio Della Sala and Alessandra Lattanzi
15. ENANTIOSELECTIVE ORGANOCATALYTIC REDUCTIONS 529
Maurizio Benaglia, Martina Bonsignore, and Andrea Genoni
16. CASCADE REACTIONS FORMING BOTH C–C BOND AND C–HETEROATOM BOND 559
Damien Bonne, Thierry Constantieux, Yoann Coquerel, and Jean Rodriguez
17. ORGANOCATALYSIS IN THE SYNTHESIS OF NATURAL PRODUCTS 587
Yongcheng Ying and Xuefeng Jiang
INDEX 629
