Description
Book SynopsisThe need for customized stem cell therapies for specific conditions will be a major issue in the coming decades. This unique book by experts in the field reviews the subject as it stands today. Its coverage includes: basic and applied stem cell research and history; sources of adult stem cells; a comparison of difficulties in derivation, and the applications of embryonic and adult stem cells. Specific topics dealt with include advantages and problems associated with stem cell / matrix interactions and stem cell differentiation, difficulties using stem cells for clinical application, stem cell based tissue engineering - myth or reality, stem cells and immunity, natural biological matrices versus synthetic (biocompatibility and integration), stem cell delivery, labeling, imaging and tracking, bioreactors: 2D and 3D cell culturing for in-vitro studies and for stem cell implantation, ethical and safety issues and Good Manufacturing Practice (GMP).
Table of ContentsPART I: Stem cells sources for practical regenerative medicine; Clinical applications of stem cells; Embryonic and adult HSC; Adult non-hematopoietic stem cells: characterization, isolation; Screening Approaches for the Characterization of Stem Cells for regenerative medicine; Part II: TISSUE REGENERATION and STEM CELL ENGINEERING; MSC as vector for cancer therapies; Promises limitations in adult cell based tissue regeneration; Re-programming stem cells and induced adult stem cells; Culturing non-hematopoietic stem cells and requirements of GMP in stem cell based therapies; Stem cells as vectors of genes; PART III: ORGAN TRAGETTED TISSUE REPAIR WITH STEM CELLS; Regeneration of bone; Regeneration of cartilage; Stem cells based replacement tissue for muscle and heart repair; Regeneration of the vasculature; Regeneration of the pancreas/islets and liver; Treating neurodegenerative tissue with embryonic stem cells; Regeneration of the genitourinary system; Strategies to adjust immunomodulation by adult stem cells; Engineering of stem cell homing and labelling of stem cells
