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Book Synopsis
In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed ''sperm chromatin condensation''. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.

Sperm Nuclear Maturation: A Basic & Clinical

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    A Paperback / softback by Ali Reza Talebi

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      Book details

      Publisher Nova Science Publishers Inc
      Published 21 October 2011
      ISBN-13 9781616681944
      978-1616681944
      ISBN-10 1616681942
      Also in:
      Computational biology / bioinformatics Genetics (non-medical)

      Description

      Book Synopsis
      In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed ''sperm chromatin condensation''. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.

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