Description
Book SynopsisOnce the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regulatory functions of ROS and RNS in physiological and pathophysiological states.
An exploration of the main questions of signaling mechanisms of reactive oxygen and nitrogen species in enzymatic processes, this book draws attention to the chemical mechanisms of these reactions. It elucidates the differences between signaling functions and damaging effects of ROS and RNS in biological systems. The text also covers free radical signaling processes catalyzed by enzymes, producers of superoxide and nitric oxide that are able to use produced ROS and RNS as signaling species in their own catalytic
Table of Contents
Introduction. Formation of superoxide by major enzyme-catalyzed reactions. Formation of nitric oxide by no synthases. Formation of reactive oxygen and nitrogen species originated from superoxide and nitric oxide. Mechanisms of nucleophilic and one-electron transfer reactions of superoxide and NO. Signaling functions of superoxide and nitric oxide in heterolytic (nucleophilic) reactions. Mitochondrial disorders initiated by reactive oxygen and nitrogen species. Antagonistic signaling by superoxide and nitric oxide in pathological processes. Participation of superoxide and nitric oxide in apoptosis. Competition between superoxide and nitric oxide in aging and senescence.
