Description
Book SynopsisIn the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention.
Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes
Table of Contents
Vertebrate Visual Phototransduction. Biophysical Approaches to the Study of G-protein Structure and Function. Photoactivation of Rhodopsin and Signal Transfer to Transducin. How Rod Arrestin Achieved Perfection: Regulation of its Availability and Binding Selectivity. Function and Regulation of PDE6. Biochemical Characterization of Phototransduction RGS9-1 GAP Complex. Guanylate Cyclase-Based Signaling in Photoreceptors and Retina. Transgenic Strategies for Analysis of Photoreceptor Function. Vertebrate Non-Visual Phototransduction. Melanopsin Signaling and Non-Visual Ocular Photoreception. Invertebrate Visual Phototransduction. Phototransduction in Drosophila: Use of Microarrays in Cloning Genes Identified by Chemically Induced Mutations causing ERG Defects. Insulin Receptor-Based Signaling in the Vertebrate Retina. Insulin Receptor-Based Signaling in the Retina. Probing the Interactions between the Retinal Insulin Receptor and its Downstream Effectors. Signal Transduction in Vertebrate Retinal Development and Vascular Homeostasis. Signal Transduction in Retinal Progenitor Cells. Probing the Hedgehog Pathway in Retinal Development. Thrombospondin-1 Signal Transduction and Retinal Vascular Homeostasis. Lipid Mediators and Signaling in the RPE
Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium.
