Description
Book SynopsisThis book focuses on Barrett’s Esophagus (BE), a clinical condition that must be evaluated in all patients affected by chronic GERD, and with an important link to esophageal cancer. Divided into four sections (morphological background, epidemiology and natural history, diagnosis, and treatments), this handy volume provides the latest indications regarding endoscopic approaches (first level and advanced endoscopy), pathological studies (pathology and molecular biology), and state-of-the-art therapeutic options (medical, endoscopic, and surgical) for BE. As such, it offers a valuable reference guide for all professionals involved in the management of BE (gastroenterologists, endoscopists, pathologists and surgeons), offering them a comprehensive overview and deeper understanding of this seemingly superficial disease.
Trade Review“This is a nice book. It is unique in its emphasis on the variety of topics related to Barrett's esophagus, but it is a very focused book, which will lack the global appeal of a more comprehensive one. However, for practitioners who treat patients with GERD and Barrett's, this will be a nice adjunct to their practice.” (Peter Nau, Doody's Book Reviews, April 12, 2019)
Table of ContentsPart I Morphologic backgrounds
1 Macroscopic anatomy of esophagus
Stefania Montagnani, Clotilde Castaldo
2 Microscopic anatomy and histology of esophagus
Stefania Montagnani, Franca Di Meglio
Part II Epidemiology and natural history
3 Definition and epidemiology of Barrett’s esophagus
Alessandra Romiti, Rocco Maurizio Zagari
4 Pathophysiolgy of esophageal reflux disease and natural history of Barrett’s esophagus
Paola Iovino, Antonella Santonicola, Nigel J Trudgill
Gastro-esophageal reflux disease
Natural history of Barrett’s esophagus
Natural history of non dysplastic Barrett’s esophagus
Natural history of Barrett’s esophagus indefinite for dysplasia
Natural history of Barrett’s esophagus with low grade dysplasia
Natural history of Barrett’s esophagus with high grade dysplasia
5 Obesity: Barrett’s esophagus and esophageal cancer risk
Jan Marc Chevallier, Sonja Chiappetta, Mario Musella
Introduction
Factors leading to GERD
Obesity, Barrett’s ulcer, and risk of cancer
Bariatric surgery and risk of GERD
GERD following restrictive procedures
GERD following gastric by-pass procedures
Part III Diagnosis
6 First level endoscopy in Barrett’s esophagus: endoscopic pictures, Prague classification and biopsy protocols
Massimo Conio, Antonella De Ceglie, Mattia Crespi
Endoscopic pictures
Prague classification
Biopsy protocol
7 Augmented endoscopy in Barrett’s esophagus: zoom endoscopy, traditional, and virtual chromoendoscopy
Giuseppe Galloro, Raffaele Manta, Nico Pagano, Teresa Russo, Donato Alessandro Telesca, Andrea Parodi, Cesare Formisano
Introduction
Traditional chromoendoscopy
High definition, zoom, and magnifying endoscopy
Computed virtual chromoendoscopy
8 Confocal LASER endomicroscopy in Barrett’s esophagus: is it a clinical resource or still a research procedure?
Giovanni Domenico De Palma, Gianluca Cassese, Gaetano Luglio
Confocal LASER endomicroscopy: theoretical and practical bases
Technical notes
CLE for Barrett’s esophagus management
Current limitations and possibilities for future development
Conclusions
9 Histology: the different points of view on Barrett’s esophagus
Vincenzo Villanacci, Karel Geboes, Tiziana Salviato, Gabrio Bassotti
Normal esophagus
Endoscopic and microscopic diagnosis of Barrett’s esophagus
Is all intestinal metaplasia equivalent to Barrett’s esophagus?
Dysplasia in Barrett’s esophagus
10 The role of molecular biology in diagnosis and follow-up of Barrett’s esophagus
Karen Geboes, Anne Hoorens
Introduction
Molecular pathways implicated in development of Barrett’s esophagus
Molecular markers for the diagnosis
Markers for the diagnosis of dysplasia
Genome-wide association studies for the development of Barrett’s esophagus
Molecular pathways implicated in the transition of Barrett’s esophagus to early adenocarcinoma
Molecular biology of progression to adenocarcinoma
Molecular markers for the diagnosis of progression to EAC.
Genetic changes involved in the progression from BE to EAC.
Biomarker development
Conclusions
11 Timing and protocols of clinical and endoscopic surveillance of Barrett’s esophagus
Carlo Calabrese, Marco Salice, Nico Pagano, Raffaele Manta, Fernando Rizzello
Protocol
Part IV Treatments
12 Lifestyles, medical therapy, and chemoprevention
Giancarlo Sarnelli, Alessandra D’Alessandro, Raf Bisschops
Physical activity and diet
Smoking and alcohol intake
Chemoprevention
13 Photodynamic therapy
Raffaele Manta, Dolores Sgambato, Nico Pagano, Giuseppe Galloro
Introduction
Technique
Data of literature
Limits
Controindications
State of the art
14 Cryotherapy
Nico Pagano, Raffaele Manta, Giuseppe Galloro
Introduction
Physical principles and technical consideration
Clinical results
Conclusions
15 Endoscopic resections: EMR and ESD
Filippo Catalano, Seichiro Abe, Yutaka Saito
16 Radiofrequency ablation
Jason Samarasena, David Lee, Kenneth J Chang
Introduction
Indications
Equipment
Technique
Post procedure
Efficacy
Adverse events
Cost-effectiveness analysis
Buried Barrett’s Esophagus
Conclusions
17 What we have to do after the treatment of metaplasia or dysplasia in Barrett’s esophagus? Protocols and timing of follow-up in the treated patient
Jose Miguel Esteban
Introduction
Endoscopic therapies of Barrett’s esophagus
Surveillance after endoscopic therapy
Surveillance Strategies
Publications regarding Protocols and Timing for surveillance
Protocols and timing of follow-up in the treated patient recommendations
Special considerations
Conclusions
18 Is there a role for the surgeon in therapeutic management of Barrett esophagus?
Uberto Fumagalli Romario, Paul Magnus Schneider
Introduction
Does BE regress after ARS and/or does ARS reduce the cancer risk in BE?
Which type of surgery for short and long segment Barrett's esophagus ?
Role of ARS to prevent BE remission following endoscopic ablation procedures
Role of ARS to prevent BE recurrence or progression after endoscopic ablation procedures
19 Early adenocarcinoma in Barrett esophagus: is this an endoscopic or a surgical problem?
Antonello Trecca, Takuji Gotoda
