Description
Book SynopsisThe tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use
For physicians monitoring a patient''s progress, efficacy of treatment is often linked to a patient''s response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use.
Covering a host of common therapeutic drugs as well as specific types of interference in immun
Table of Contents
Preface vii
Chapter 1 An Introduction to Tests Performed in Toxicology Laboratories 1
Chapter 2 Challenges in Drugs of Abuse Testing 31
Chapter 3 False-Positive Results Using Immunoassays for Drugs of Abuse Testing 53
Chapter 4 True-Positive Drugs of Abuse Test Results Due to Use of Prescriptions and Nonprescription Drugs 67
Chapter 5 When Toxicology Report Is Negative in a Suspected Overdosed Patient:
The World of Designer Drugs 85
Chapter 6 Abuse of Magic Mushrooms, Peyote Cactus, Khat, and Solvents: No Readily Available Laboratory Tests 101
Chapter 7 Limitations of Blood Alcohol Measurements Using Automated Analyzers and Breath Analyzers 121
Chapter 8 Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol 139
Chapter 9 Poisoning with Warfarin and Superwarfarin: What Can Laboratory Testing Do? 161
Chapter 10 Plant Poisoning and the Clinical Laboratory 185
Chapter 11 Sources of Erroneous Results in Therapeutic Drug Monitoring Due to Preanalytical Errors, High Bilirubin, Hemolysis, and Lipids 213
Chapter 12 Challenges in Therapeutic Drug Monitoring of Digoxin Using Immunoassays 237
Chapter 13 Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants 265
Chapter 14 Interference in Immunoassays Used to Monitor Tricyclic Antidepressants 293
Chapter 15 Therapeutic Drug Monitoring of Immunosuppressants: Limitations of Immunoassays and the Need for Chromatographic Methods 323
Chapter 16 Effect of Drug–Herb Interactions on Therapeutic Drug Monitoring 355
Chapter 17 Pharmacogenomics and the Toxicology Laboratory 385
Chapter 18 Approaches for Eliminating Interference/Discordant Specimens in Therapeutic Drug Monitoring and Drugs of Abuse Testing 411
Index 429
