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Book Synopsis
Vitamin A-storing cells in the liver exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule, and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. In physiological conditions, these cells play pivotal roles in the regulation of vitamin A homeostasis. In pathological conditions such as hepatic fibrosis or liver cirrhosis, hepatic stellate cells lose vitamin A, and synthesise a large amount of extracellular matrix components including collagen, proteoglycan, glycosaminoglycan, and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. This book discusses and presents research on vitamin A-storing cells.

Regulation of Vitamin A Homeostasis by the

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    A Paperback / softback by Haruki Senoo, Kiwamu Yoshikawa, Yoshihiro Mezaki

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      Publisher: Nova Science Publishers Inc
      Publication Date: Publication Date: 16/02/2011
      ISBN13: 9781617613135, 978-1617613135
      ISBN10: 1617613134

      Description

      Book Synopsis
      Vitamin A-storing cells in the liver exist in the space between parenchymal cells and liver sinusoidal endothelial cells of the hepatic lobule, and store 50-80% of vitamin A in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. In physiological conditions, these cells play pivotal roles in the regulation of vitamin A homeostasis. In pathological conditions such as hepatic fibrosis or liver cirrhosis, hepatic stellate cells lose vitamin A, and synthesise a large amount of extracellular matrix components including collagen, proteoglycan, glycosaminoglycan, and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. This book discusses and presents research on vitamin A-storing cells.

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